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    TTLL3A Tubulin tyrosine ligase-like 3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TTLL3Aprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031854
    Locus tag
    Dmel_CG11323
    See related
    AllianceGenome:FB:FBgn0031854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11323; DmCG11323; Dmel\CG11323; dmTTLL3A; TTLL3
    Summary
    Enables protein-glycine ligase activity, elongating and protein-glycine ligase activity, initiating. Involved in protein polyglycylation. Located in microtubule cytoskeleton. Orthologous to several human genes including TTLL8 (tubulin tyrosine ligase like 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL3A in Genome Data Viewer
    Location:
    27A2-27A2; 2-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6736364..6740188, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6736364..6740188, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Liprin-alpha Neighboring gene Tubulin tyrosine ligase-like 3B Neighboring gene meng-po Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    3. Oviposition behaviour in Drosophila melanogaster: Genetic and behavioural decoupling between oviposition acceptance and preference for natural fruits. Fanara JJ, et al. J Evol Biol, 2023 Jan. PMID 36357966
    4. Drosophila spermiogenesis: Big things come from little packages. Fabian L, et al. Spermatogenesis, 2012 Jul 1. PMID 23087837, Free PMC Article
    5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, elongating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, initiating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, initiating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 3A
    Names
    CG11323-PA
    TTLL3A-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6736364..6740188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135225.2 → NP_609069.1  tubulin tyrosine ligase-like 3A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM91
      Related
      FBpp0078935
      Conserved Domains (1) summary
      pfam03133
      Location:342 → 640
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM91.1 Q9VM91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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