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    Sr-CII Scavenger receptor class C, type II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sr-CIIprovided by FlyBase
    Official Full Name
    Scavenger receptor class C, type IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020377
    Locus tag
    Dmel_CG8856
    See related
    AllianceGenome:FB:FBgn0020377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8856; CT25430; Dmel\CG8856; dSR-CII; SR-CII
    Summary
    Predicted to be involved in nervous system development. Predicted to be located in membrane. Is expressed in central brain primordium; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sr-CII in Genome Data Viewer
    Location:
    48E10-48E10; 2-66 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12208893..12212155, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8096398..8099660, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S11 Neighboring gene long non-coding RNA:CR45276 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans. Lazzaro BP. Genetics, 2005 Apr. PMID 15716507, Free PMC Article
    2. Genetic basis of natural variation in D. melanogaster antibacterial immunity. Lazzaro BP, et al. Science, 2004 Mar 19. PMID 15031506
    3. Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria. Lazzaro BP, et al. Genetics, 2006 Nov. PMID 16888344, Free PMC Article
    4. Phagocytosis in Drosophila: From molecules and cellular machinery to physiology. Melcarne C, et al. Insect Biochem Mol Biol, 2019 Jun. PMID 30953686
    5. Genes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis. Zúñiga A, et al. BMC Biol, 2009 Sep 22. PMID 19772636, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class C, type II
    Names
    CG8856-PA
    CG8856-PB
    Sr-CII-PA
    Sr-CII-PB
    scavenger receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12208893..12212155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201979.2 → NP_001188908.1  scavenger receptor class C, type II, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8V0, Q5ELY0
      Conserved Domains (5) summary
      cd06263
      Location:136 → 308
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd00033
      Location:22 → 72
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:77 → 125
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00629
      Location:136 → 312
      MAM; MAM domain, meprin/A5/mu
      pfam01033
      Location:341 → 387
      Somatomedin_B; Somatomedin B domain

    2. NM_079981.3 → NP_524720.2  scavenger receptor class C, type II, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524720.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8V0, Q5ELY0
      Related
      FBpp0087112
      Conserved Domains (5) summary
      cd06263
      Location:136 → 308
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd00033
      Location:22 → 72
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:77 → 125
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00629
      Location:136 → 312
      MAM; MAM domain, meprin/A5/mu
      pfam01033
      Location:341 → 387
      Somatomedin_B; Somatomedin B domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8V0 A1Z8V0
    Q5ELX1 Q5ELX1
    Q5ELX2 Q5ELX2
    Q5ELX3 Q5ELX3
    Q5ELX4 Q5ELX4
    Q5ELX6 Q5ELX6
    Q5ELX7 Q5ELX7
    Q5ELX8 Q5ELX8
    Q5ELX9 Q5ELX9
    Q5ELY0 Q5ELY0
    Q5ELY3 Q5ELY3
    Q5ELY5 Q5ELY5
    Q5ELY7 Q5ELY7
    Q5ELY8 Q5ELY8
    Q8IGQ7 Q8IGQ7
    Q9U3W0 Q9U3W0

    Gene LinkOut

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