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    Drip drip [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36236, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dripprovided by FlyBase
    Official Full Name
    dripprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015872
    Locus tag
    Dmel_CG9023
    See related
    AllianceGenome:FB:FBgn0015872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-48Aa; CG9023; Dmel\CG9023; drip; DRIP; I
    Summary
    Enables water channel activity. Involved in renal water homeostasis; transmembrane transport; and water transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including Malpighian tubule Type II cell; adult head; embryonic/larval gut; embryonic/larval pharynx; and posterior spiracle primordium. Human ortholog(s) of this gene implicated in several diseases, including Bothnian type palmoplantar keratoderma; cataract (multiple); nephrogenic diabetes insipidus (multiple); optic nerve disease (multiple); and transverse myelitis. Orthologous to several human genes including AQP1 (aquaporin 1 (Colton blood group)) and AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drip in Genome Data Viewer
    Location:
    47F11-47F11; 2-64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11411203..11429645, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7298708..7317150, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43771 Neighboring gene prip

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury(†). Schiffman HJ, et al. Br J Anaesth, 2020 Jul. PMID 32466842, Free PMC Article
    2. High sucrose diet induces morphological, structural and functional impairments in the renal tubules of Drosophila melanogaster: A model for studying type-2 diabetes mediated renal tubular dysfunction. Rani L, et al. Insect Biochem Mol Biol, 2020 Oct. PMID 32735915
    3. Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster. Gautam NK, et al. Int J Dev Biol, 2010. PMID 20209436
    4. Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Cabrero P, et al. Proc Natl Acad Sci U S A, 2014 Sep 30. PMID 25228763, Free PMC Article
    5. SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water. Li H, et al. J Cell Biol, 2019 Dec 2. PMID 31645458, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in multicellular organismal-level water homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in renal water homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in water transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    drip
    Names
    CG9023-PA
    CG9023-PB
    CG9023-PC
    CG9023-PD
    CG9023-PE
    CG9023-PF
    CG9023-PG
    Drip-PA
    Drip-PB
    Drip-PC
    Drip-PD
    Drip-PE
    Drip-PF
    Drip-PG
    aquaporin
    drosophila integral protein
    transcript group I

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11411203..11429645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299387.1 → NP_001286316.1  drip, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG55
      Conserved Domains (1) summary
      cl00200
      Location:23 → 227
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    2. NM_001273964.1 → NP_001260893.1  drip, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFD6
      Conserved Domains (1) summary
      cl00200
      Location:23 → 227
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    3. NM_078973.3 → NP_523697.1  drip, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24148, Q3KN56, Q8MKY6, Q9V5Z7
      UniProtKB/TrEMBL
      H6V591
      Related
      FBpp0087241
      Conserved Domains (1) summary
      cl00200
      Location:23 → 227
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    4. NM_165833.3 → NP_725051.2  drip, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725051.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24148, Q3KN56, Q8MKY6, Q9V5Z7
      UniProtKB/TrEMBL
      H6V591
      Related
      FBpp0087240
      Conserved Domains (1) summary
      cl00200
      Location:23 → 227
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    5. NM_001273963.1 → NP_001260892.1  drip, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFN8
      Conserved Domains (1) summary
      cl00200
      Location:17 → 221
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    6. NM_001273961.1 → NP_001260890.1  drip, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDC9
      Conserved Domains (1) summary
      cl00200
      Location:21 → 225
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    7. NM_001273962.1 → NP_001260891.1  drip, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET4
      Conserved Domains (1) summary
      cl00200
      Location:20 → 224
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KET4 A0A0B4KET4
    A0A0B4KFD6 A0A0B4KFD6
    A0A0B4KFN8 A0A0B4KFN8
    A0A0B4LG55 A0A0B4LG55
    F3YDC9 F3YDC9
    Q9V5Z7.2 Q9V5Z7

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