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    Ptp10D Protein tyrosine phosphatase 10D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32115, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptp10Dprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase 10Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004370
    Locus tag
    Dmel_CG1817
    See related
    AllianceGenome:FB:FBgn0004370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10D; CG1817; CT4920; Dmel\CG1817; dptp; DPTP; Dptp10D; DPTP10D; DPTP[[10D]]; Ptp10; ptp10d; ptp10D; Ptp10d; PTP10D; R-PTP 10D; RPTP10d
    Summary
    Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including long-term memory; negative regulation of signal transduction; and nervous system development. Located in apical part of cell and axon. Is expressed in several structures, including adult antennal lobe; adult central complex; brain; embryonic/larval tracheal section; and tract. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ptp10D in Genome Data Viewer
    Location:
    10D1-10D4; 1-35 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11622015..11677338)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11516048..11571371)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Replication protein A3 Neighboring gene Methoprene-tolerant Neighboring gene Valette Neighboring gene bifocal

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein tyrosine phosphatase 10D
    Names
    CG1817-PB
    CG1817-PE
    CG1817-PF
    CG1817-PG
    CG1817-PH
    CG1817-PI
    Ptp10D-PB
    Ptp10D-PE
    Ptp10D-PF
    Ptp10D-PG
    Ptp10D-PH
    Ptp10D-PI
    protein tyrosine phosphatase 10B
    NP_001138187.1
    NP_001259453.1
    NP_001259454.1
    NP_727544.2
    NP_996413.2
    NP_996414.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11622015..11677338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206691.3NP_996414.2  protein tyrosine phosphatase 10D, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996414.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
      Conserved Domains (4) summary
      smart00194
      Location:12721525
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:12981525
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:583671
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:220304
      fn3; Fibronectin type III domain
    2. NM_001144715.2NP_001138187.1  protein tyrosine phosphatase 10D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35992
      Conserved Domains (4) summary
      smart00194
      Location:12721525
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:12981525
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:583671
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:220304
      fn3; Fibronectin type III domain
    3. NM_001272525.1NP_001259454.1  protein tyrosine phosphatase 10D, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35992
      Conserved Domains (4) summary
      smart00194
      Location:12721525
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:12981525
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:583671
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:220304
      fn3; Fibronectin type III domain
    4. NM_001272524.1NP_001259453.1  protein tyrosine phosphatase 10D, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35992
      Conserved Domains (4) summary
      smart00194
      Location:12941547
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:13201547
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:599687
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:236320
      fn3; Fibronectin type III domain
    5. NM_206690.2NP_996413.2  protein tyrosine phosphatase 10D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996413.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
      Conserved Domains (4) summary
      smart00194
      Location:12721525
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:12981525
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:583671
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:220304
      fn3; Fibronectin type III domain
    6. NM_167292.3NP_727544.2  protein tyrosine phosphatase 10D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727544.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35992
      Conserved Domains (4) summary
      smart00194
      Location:12721525
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:12981525
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:583671
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:220304
      fn3; Fibronectin type III domain