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    Dnaaf3 Dynein axonemal assembly factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnaaf3provided by FlyBase
    Official Full Name
    Dynein axonemal assembly factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0034352
    Locus tag
    Dmel_CG17669
    See related
    AllianceGenome:FB:FBgn0034352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17669; Dmel\CG17669
    Summary
    Involved in axonemal dynein complex assembly. Is active in cytosol. Is expressed in Johnston organ; chordotonal neurons; and male germline cell. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 2. Orthologous to human DNAAF3 (dynein axonemal assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dnaaf3 in Genome Data Viewer
    Location:
    55C9-55C9; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18452737..18454462, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14340242..14341967, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19 Neighboring gene roswell Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase E11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article
    2. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
    3. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article
    4. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    5. Drosophila auditory organ genes and genetic hearing defects. Senthilan PR, et al. Cell, 2012 Aug 31. PMID 22939627

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonemal dynein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal assembly factor 3
    Names
    CG17669-PA
    Dnaaf3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18452737..18454462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137492.2 → NP_611336.1  dynein axonemal assembly factor 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZB91, B6IDP0, Q5U0U7
      Related
      FBpp0085901
      Conserved Domains (3) summary
      pfam14737
      Location:46 → 124
      DUF4470; Domain of unknown function (DUF4470)
      pfam14740
      Location:156 → 451
      DUF4471; Domain of unknown function (DUF4471)
      cl00388
      Location:472 → 522
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB91.1 A1ZB91

    Gene LinkOut

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