rswl roswell [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rswlprovided by FlyBase
Official Full Name: roswellprovided by FlyBase
Primary source: FLYBASE:FBgn0034351
Locus tag: Dmel_CG5190
See related: AllianceGenome:FB:FBgn0034351
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5190; Dmel\CG5190; MRPP1; TRMT10C
Summary: Predicted to enable tRNA (adenine(9)-N1)-methyltransferase activity; tRNA (guanosine(9)-N1)-methyltransferase activity; and tRNA binding activity. Involved in mitochondrial tRNA processing. Located in mitochondrion. Part of mitochondrial ribonuclease P complex. Is expressed in embryonic/larval midgut and organism. Used to study combined oxidative phosphorylation deficiency 30. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 30. Orthologous to human TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18451284..18452736)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14338789..14340241)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables tRNA (adenine(9)-N1)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA (guanosine(9)-N1)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA 5'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain