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    GstE11 Glutathione S transferase E11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstE11provided by FlyBase
    Official Full Name
    Glutathione S transferase E11provided by FlyBase
    Primary source
    FLYBASE:FBgn0034354
    Locus tag
    Dmel_CG5224
    See related
    AllianceGenome:FB:FBgn0034354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg5224; CG5224; Dmel\CG5224; gste11; GSTE11
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in adult head; larval muscle system; organism; and trunk mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE11 in Genome Data Viewer
    Location:
    55D1-55D1; 2-86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18503608..18505025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14391113..14392530)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dynein axonemal assembly factor 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoenolpyruvate carboxykinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    2. Expression Patterns of Drosophila Melanogaster Glutathione Transferases. Gonis E, et al. Insects, 2022 Jul 7. PMID 35886788, Free PMC Article
    3. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco A, et al. Mol Biol Evol, 2004 Jan. PMID 14595091
    4. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
    5. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Saisawang C, et al. Biochem J, 2012 Feb 15. PMID 22082028

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E11
    Names
    CG5224-PA
    CG5224-PB
    GstE11-PA
    GstE11-PB
    NP_001286575.1
    NP_611339.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18503608..18505025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299646.1 → NP_001286575.1  glutathione S transferase E11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVZ8
      Conserved Domains (3) summary
      cd03177
      Location:94 → 211
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:5 → 198
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:5 → 78
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    2. NM_137495.3 → NP_611339.1  glutathione S transferase E11, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVZ8
      Related
      FBpp0085876
      Conserved Domains (3) summary
      cd03177
      Location:94 → 211
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:5 → 198
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:5 → 78
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVZ8 Q7JVZ8

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