RPS10 ribosomal protein S10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS10provided by HGNC
Official Full Name: ribosomal protein S10provided by HGNC
Primary source: HGNC:HGNC:10383
See related: Ensembl:ENSG00000124614 MIM:603632; AllianceGenome:HGNC:10383
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S10; DBA9; eS10
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in ovary (RPKM 559.9), lymph node (RPKM 396.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (34417454..34426069, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (34241303..34249921, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (34385231..34393846, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Znf598-mediated Rps10/eS10 ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development.
Title: Znf598-mediated Rps10/eS10 ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development.
Identification of novel mutations in patients with Diamond-Blackfan anemia and literature review of RPS10 and RPS26 mutations.
Title: Identification of novel mutations in patients with Diamond-Blackfan anemia and literature review of RPS10 and RPS26 mutations.
Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor 1A (eIF1A) which interacts with both RPS3 and RPS10e.
Title: Efficient and Accurate Translation Initiation Directed by TISU Involves RPS3 and RPS10e Binding and Differential Eukaryotic Initiation Factor 1A Regulation.
These results are consistent with a model in which the Nef protein by binding to two components of the 40S small ribosomal subunit, RPS10 and 18S rRNA, and to a lesser extent to tRNAs, could lead to decreased protein synthesis.
Title: The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA.
A novel mutation of ribosomal protein S10 gene in a Japanese patient with diamond-Blackfan anemia.
Title: A novel mutation of ribosomal protein S10 gene in a Japanese patient with diamond-Blackfan anemia.
Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.
Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.
Mutations in the RPS10 and RPS26 genes in DBA patients affect the function of the proteins in rRNA processing.
Title: Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Title: Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Diamond-Blackfan anemia 9 MedGen: C2750081 OMIM: 613308 GeneReviews: Diamond-Blackfan Anemia	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef inhibits translation in vitro by interacting with two components of the 40S small ribosomal subunits, the RPS10 protein and the 18S rRNA	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RP_S10_2 (e-PCR)
- UniSTS:19762

D20S1016 (e-PCR)
- UniSTS:1132

D6S315E (e-PCR)
- UniSTS:147325

RP_S10 (e-PCR)
- UniSTS:32445

Readthrough RPS10-NUDT3

Readthrough gene: RPS10-NUDT3, Included gene: NUDT3

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	HDA more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	HDA more info	PubMed
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in ribosome	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein eS10

Names: 40S ribosomal protein S10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023200.1 RefSeqGene

Range

5031..13646

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1138

mRNA and Protein(s)

NM_001014.5 → NP_001005.1 small ribosomal subunit protein eS10

See identical proteins and their annotated locations for NP_001005.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL157372, BC001032, BG940847

Consensus CDS

CCDS4792.1

UniProtKB/Swiss-Prot

B2R4E3, P46783, Q5TZC0

UniProtKB/TrEMBL

Q59GE4

Related

ENSP00000497917.1, ENST00000648437.1

Conserved Domains (1) summary

pfam03501
Location:3 → 97

S10_plectin; Plectin/S10 domain
NM_001203245.3 → NP_001190174.1 small ribosomal subunit protein eS10

See identical proteins and their annotated locations for NP_001190174.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL157372, BC071946, BG532491

Consensus CDS

CCDS4792.1

UniProtKB/Swiss-Prot

B2R4E3, P46783, Q5TZC0

UniProtKB/TrEMBL

Q59GE4

Related

ENSP00000481646.1, ENST00000621356.3

Conserved Domains (1) summary

pfam03501
Location:3 → 97

S10_plectin; Plectin/S10 domain
NM_001204091.2 → NP_001191020.1 small ribosomal subunit protein eS10

See identical proteins and their annotated locations for NP_001191020.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL157372, BU956627

Consensus CDS

CCDS4792.1

UniProtKB/Swiss-Prot

B2R4E3, P46783, Q5TZC0

UniProtKB/TrEMBL

Q59GE4

Conserved Domains (1) summary

pfam03501
Location:3 → 97

S10_plectin; Plectin/S10 domain