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    Amy-p Amylase proximal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amy-pprovided by FlyBase
    Official Full Name
    Amylase proximalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000079
    Locus tag
    Dmel_CG18730
    See related
    AllianceGenome:FB:FBgn0000079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-Amy; alpha-AMY; amy; Amy; AMY; Amy(p); amy-p; Amy-P; Amy-proximal; Amy1; Amy2; Amy4; Amy5; AmyA; AmyD; Amyn.sp; CG18640; CG18730; Dmel\CG18730
    Summary
    Enables alpha-amylase activity and calcium ion binding activity. Involved in carbohydrate catabolic process. Located in extracellular region. Is expressed in embryonic central brain neurons; embryonic/larval tracheal section; ganglia; lateral cord neurons; and midgut. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Amy-p in Genome Data Viewer
    Location:
    53F11-53F12; 2-81 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17118636..17120303, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13006141..13007808, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45272 Neighboring gene Serpin 53F Neighboring gene Amylase distal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and Functional Characterization of Drosophila melanogaster α-Amylase. Rhimi M, et al. Molecules, 2023 Jul 11. PMID 37513201, Free PMC Article
    2. Enzymatic characterization of recombinant α-amylase in the Drosophila melanogaster species subgroup: is there an effect of specialization on digestive enzyme? Commin C, et al. Genes Genet Syst, 2013. PMID 24463528
    3. Naturally occurring variation in the restriction map of the amy region of Drosophila melanogaster. Langley CH, et al. Genetics, 1988 Jul. PMID 17246437, Free PMC Article
    4. A Drosophila gene promoter is subject to glucose repression in yeast cells. Hickey DA, et al. Proc Natl Acad Sci U S A, 1994 Nov 8. PMID 7526389, Free PMC Article
    5. A molecular explanation of frequency-dependent selection in Drosophila. Haj-Ahmad Y, et al. Nature, 1982 Sep 23. PMID 6180326

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-amylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-amylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    amylase proximal
    Names
    Amy-p-PA
    Amy-p-PB
    Amylase-A
    CG18730-PA
    CG18730-PB
    alpha-amylase
    alpha-amylase proximal
    amylase
    NP_001286518.1
    NP_536346.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17118636..17120303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299589.1 → NP_001286518.1  amylase proximal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81641, Q27578, Q27581, Q27585, Q27882, Q27885, Q27897, Q8WP56, Q95NK4, Q969D1, Q9BH39, Q9BH72, Q9BPS5, Q9BPS6, Q9BPS7, Q9BPS8, Q9BPT0, Q9BPT1, Q9BPT2, Q9BPT3, Q9V7Z0
      UniProtKB/TrEMBL
      A0A0B4LGS0
      Conserved Domains (3) summary
      cd11317
      Location:28 → 399
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:405 → 493
      Aamy_C; Aamy_C domain
      pfam00128
      Location:54 → 342
      Alpha-amylase; Alpha amylase, catalytic domain

    2. NM_080421.4 → NP_536346.1  amylase proximal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81641, Q27578, Q27581, Q27585, Q27882, Q27885, Q27897, Q8WP56, Q95NK4, Q969D1, Q9BH39, Q9BH72, Q9BPS5, Q9BPS6, Q9BPS7, Q9BPS8, Q9BPT0, Q9BPT1, Q9BPT2, Q9BPT3, Q9V7Z0
      UniProtKB/TrEMBL
      A0A0B4LGS0
      Related
      FBpp0086155
      Conserved Domains (3) summary
      cd11317
      Location:28 → 399
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:405 → 493
      Aamy_C; Aamy_C domain
      pfam00128
      Location:54 → 342
      Alpha-amylase; Alpha amylase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGS0 A0A0B4LGS0
    P08144.1 P08144
    Q2VYA0 Q2VYA0
    Q2VYA1 Q2VYA1
    Q2VYA3 Q2VYA3

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