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    CG3168 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3168provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029896
    Locus tag
    Dmel_CG3168
    See related
    AllianceGenome:FB:FBgn0029896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LP06294; Dmel\CG3168; LP06294.5prime; Slc22a18
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including CNS glial cell; adult head; embryonic Malpighian tubule tip cell; epithelium; and ganglia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to several human genes including SV2A (synaptic vesicle glycoprotein 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3168 in Genome Data Viewer
    Location:
    6C9-6C10; 1-18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6720004..6739986, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6614037..6634019, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43461 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nicotine-Mediated Rescue of α-Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila. Olsen AL, et al. Mov Disord, 2023 Feb. PMID 36416213, Free PMC Article
    2. A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function. Wang P, et al. J Neurosci, 2004 May 12. PMID 15140922, Free PMC Article
    3. Use of a Drosophila model to identify genes regulating Plasmodium growth in the mosquito. Brandt SM, et al. Genetics, 2008 Nov. PMID 18791251, Free PMC Article
    4. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
    5. Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster. Zhang MJ, et al. Arch Insect Biochem Physiol, 2021 Mar. PMID 33590535

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3168-PA
    CG3168-PB
    CG3168-PC
    CG3168-PD
    CG3168-PE
    CG3168-PF
    CG3168-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6720004..6739986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298031.1 → NP_001284960.1  uncharacterized protein Dmel_CG3168, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    2. NM_167086.2 → NP_727117.1  uncharacterized protein Dmel_CG3168, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Related
      FBpp0070944
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    3. NM_001298028.1 → NP_001284957.1  uncharacterized protein Dmel_CG3168, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    4. NM_132117.2 → NP_572345.1  uncharacterized protein Dmel_CG3168, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Related
      FBpp0070945
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    5. NM_001298029.1 → NP_001284958.1  uncharacterized protein Dmel_CG3168, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    6. NM_167085.3 → NP_727116.1  uncharacterized protein Dmel_CG3168, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Related
      FBpp0070946
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport

    7. NM_001298030.1 → NP_001284959.1  uncharacterized protein Dmel_CG3168, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W9
      Conserved Domains (2) summary
      cd06174
      Location:154 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:149 → 598
      2A0115; benzoate transport
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3W9 Q9W3W9

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