Prestin prestin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prestinprovided by FlyBase
Official Full Name: prestinprovided by FlyBase
Primary source: FLYBASE:FBgn0036770
Locus tag: Dmel_CG5485
See related: AllianceGenome:FB:FBgn0036770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5485; CG5845; Dmel\CG5485; dpres; dPrestin; prestin; Slc26a5
Summary: Enables calcium ion transmembrane transporter activity; inorganic anion transmembrane transporter activity; and organic anion transmembrane transporter activity. Involved in bicarbonate transport; carboxylic acid transport; and inorganic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); bone disease (multiple); calcium oxalate nephrolithiasis; and diarrhea (multiple). Orthologous to several human genes including SLC26A4 (solute carrier family 26 member 4); SLC26A5 (solute carrier family 26 member 5); and SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 75A8-75A8; 3-45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17898889..17907812, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17891989..17900912, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that prestin is expressed in Johnston's organ neurons yet is not required for auditory amplification in D. melanogaster
Title: Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing.
appears suited for central roles in bicarbonate, sulfate and oxalate metabolism including generating the high pH conditions measured in the Dipteran midgut lumen
Title: Ion and solute transport by Prestin in Drosophila and Anopheles.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables formate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables solute:inorganic anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in formate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prestin

Names: CG5485-PA; Prestin-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

17898889..17907812 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140767.2 → NP_649024.1 prestin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649024.1

Status: REVIEWED

UniProtKB/TrEMBL

D2NUE0, Q9VVM6

Related

FBpp0074919

Conserved Domains (2) summary

cd07042
Location:582 → 730

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:82 → 731

sulP; high affinity sulphate transporter 1