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    Semp1 Seminal metalloprotease-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Semp1provided by FlyBase
    Official Full Name
    Seminal metalloprotease-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028944
    Locus tag
    Dmel_CG11864
    See related
    AllianceGenome:FB:FBgn0028944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AST; BACR44L22.8; BG:BACR44L22.8; CG11864; Dmel\CG11864; semp1
    Summary
    Enables endopeptidase activity. Involved in cell migration and protein processing. Located in extracellular space. Is expressed in egg; female reproductive system; oviduct; and uterus. Used to study prostate cancer. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Semp1 in Genome Data Viewer
    Location:
    35D3-35D3; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15612494..15613335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15612494..15613335, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kekkon 3 Neighboring gene long non-coding RNA:CR44865 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional and structural insights into astacin metallopeptidases. Gomis-Rüth FX, et al. Biol Chem, 2012 Oct. PMID 23092796
    2. Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila. Sepil I, et al. Proc Natl Acad Sci U S A, 2020 Jul 21. PMID 32611817, Free PMC Article
    3. Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities. Misra S, et al. Toxicol Sci, 2014 Sep. PMID 24973093, Free PMC Article
    4. A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity. Laflamme BA, et al. Genetics, 2014 Apr. PMID 24514904, Free PMC Article
    5. Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F. Mueller JL, et al. Genetics, 2008 Mar. PMID 18245332, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Semp1 (CG11864) activational cleavage in male ejaculates necessitates female factors for full activity; however in females, Semp1 is fully activated but substantially delayed.
      Title: A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity.
    2. Astacin-type metalloprotease CG11864 in seminal fluid is necessary to process two other seminal proteins: the ovulation hormone ovulin (Acp26Aa) and the sperm storage protein Acp36DE.
      Title: Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    seminal metalloprotease-1
    Names
    CG11864-PA
    Semp1-PA
    NP_609756.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15612494..15613335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135912.3 → NP_609756.1  seminal metalloprotease-1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609756.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZE8, Q9VJN9, S0ASJ3
      UniProtKB/TrEMBL
      B1P791, B1P794, B1P797, B1P799
      Related
      FBpp0080342
      Conserved Domains (2) summary
      cd04280
      Location:55 → 245
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:53 → 249
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJN9.1 Q9VJN9

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