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    GCS1 Glucosidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCS1provided by FlyBase
    Official Full Name
    Glucosidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030289
    Locus tag
    Dmel_CG1597
    See related
    AllianceGenome:FB:FBgn0030289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1597; Dmel\CG1597
    Summary
    Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GCS1 in Genome Data Viewer
    Location:
    10B3-10B3; 1-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11344506..11348001, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11238539..11242034, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene Kinesin associated protein 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Characterization of a Venom Protein Calreticulin in the Ectoparasitoid Pachycrepoideus vindemiae. Yang L, et al. Insects, 2019 Dec 31. PMID 31906042, Free PMC Article
    2. Effects of lamellolysin from a parasitoid wasp on Drosophila blood cells in vitro. Rizki RM, et al. J Exp Zool, 1991 Feb. PMID 1899269
    3. Microtubule inhibitors block the morphological changes induced in Drosophila blood cells by a parasitoid wasp factor. Rizki RM, et al. Experientia, 1990 Mar 15. PMID 2311722
    4. Developmental analysis of a temperature-sensitive melanotic tumor mutant inDrosophila melanogaster. Rizki TM, et al. Wilehm Roux Arch Dev Biol, 1980 Oct. PMID 28305175
    5. Drosophila larval fat body surfaces : Changes in transplant compatibility during development. Rizki RM, et al. Wilehm Roux Arch Dev Biol, 1983 Jan. PMID 28305327

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase 1
    Names
    CG1597-PB
    CG1597-PC
    GCS1-PB
    GCS1-PC
    NP_001245621.1
    NP_572707.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11344506..11348001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132479.3 → NP_572707.4  glucosidase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572707.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R68, Q9VZ04
      Conserved Domains (2) summary
      pfam03200
      Location:352 → 847
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:104 → 283
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    2. NM_001258692.2 → NP_001245621.1  glucosidase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R68, Q9VZ04
      Conserved Domains (2) summary
      pfam03200
      Location:352 → 847
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:104 → 283
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R68 Q95R68
    Q9VZ04 Q9VZ04

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