Gapvd1 GTPase activating protein and VPS9 domains 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gapvd1provided by FlyBase
Official Full Name: GTPase activating protein and VPS9 domains 1provided by FlyBase
Primary source: FLYBASE:FBgn0030286
Locus tag: Dmel_CG1657
See related: AllianceGenome:FB:FBgn0030286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1657; Dmel\CG1657; FBpp0073304; GAPVD1
Summary: Predicted to enable GTPase activating protein binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of Rab protein signal transduction and regulation of protein transport. Predicted to be active in cytosol and endocytic vesicle. Is expressed in adult fat body and spermatozoon. Used to study nephrotic syndrome. Orthologous to human GAPVD1 (GTPase activating protein and VPS9 domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11325385..11334071)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11219418..11228104)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISM Inferred from Sequence Model more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of Rab protein signal transduction	ISM Inferred from Sequence Model more info	PubMed
involved_in regulation of protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain