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    GCC88 GRIP and coiled-coil domain containing 88 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCC88provided by FlyBase
    Official Full Name
    GRIP and coiled-coil domain containing 88 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037881
    Locus tag
    Dmel_CG10703
    See related
    AllianceGenome:FB:FBgn0037881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10703; dGCC88; Dmel\CG10703
    Summary
    Enables small GTPase binding activity. Predicted to be involved in Golgi vesicle transport. Located in Golgi trans cisterna. Is expressed in adult head. Orthologous to human GCC1 (GRIP and coiled-coil domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GCC88 in Genome Data Viewer
    Location:
    86D8-86D8; 3-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11228158..11230600, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7053880..7056322, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L3 Neighboring gene SCP-containing protein C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diphthamide biosynthesis 3 Neighboring gene Arfaptin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. bicoid RNA localization requires the trans-Golgi network. Cai X, et al. Hereditas, 2019. PMID 31528161, Free PMC Article
    2. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
    3. Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Gardiol A, et al. Dev Biol, 2014 Aug 15. PMID 24951879, Free PMC Article
    4. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
    5. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. Christis C, et al. J Cell Biol, 2012 Feb 6. PMID 22291037, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GRIP and coiled-coil domain containing 88 kDa
    Names
    CG10703-PA
    GCC88 ortholog
    GCC88-PA
    dGCC88

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11228158..11230600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141798.3 → NP_650055.1  GRIP and coiled-coil domain containing 88 kDa [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGR1
      Related
      FBpp0081842
      Conserved Domains (1) summary
      pfam01465
      Location:646 → 688
      GRIP; GRIP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGR1 Q9VGR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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