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    Thoc2 THO complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thoc2provided by RGD
    Official Full Name
    THO complex subunit 2provided by RGD
    Primary source
    RGD:1561623
    See related
    EnsemblRapid:ENSRNOG00000007315 AllianceGenome:RGD:1561623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561623
    Summary
    Predicted to enable mRNA binding activity. Involved in negative regulation of neuron projection development. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 231.8), Spleen (RPKM 153.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc2 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (125500549..125615139, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (120634966..120749569, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128153824..128268327, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484131 Neighboring gene eukaryotic translation initiation factor 3, subunit K, pseudogene 2 Neighboring gene THO complex 2, pseudogene 1 Neighboring gene similar to 40S ribosomal protein S2 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene STAG2 cohesin complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability. Kumar R, et al. Am J Hum Genet, 2015 Aug 6. PMID 26166480, Free PMC Article
    2. A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. Di Gregorio E, et al. J Med Genet, 2013 Aug. PMID 23749989, Free PMC Article
    3. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. Folco EG, et al. PLoS One, 2012. PMID 22928037, Free PMC Article
    4. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
    5. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in generation of neurons ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 2
    Names
    THO complex 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191756.2 → NP_001178685.1  THO complex subunit 2

      See identical proteins and their annotated locations for NP_001178685.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1M0V4
      Related
      ENSRNOP00000102762.1, ENSRNOT00000163986.1
      Conserved Domains (5) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam12278
      Location:1448 → 1557
      SDP_N; Sex determination protein N terminal
      pfam12871
      Location:1347 → 1471
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:11 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      125500549..125615139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257504.5 → XP_006257566.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8V3, F1M0V4
      Related
      ENSRNOP00000074749.2, ENSRNOT00000081880.3
      Conserved Domains (4) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam12278
      Location:1475 → 1584
      SDP_N; Sex determination protein N terminal
      pfam16134
      Location:11 → 566
      THOC2_N; THO complex subunit 2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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