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    Lrrc3b leucine rich repeat containing 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc3bprovided by RGD
    Official Full Name
    leucine rich repeat containing 3Bprovided by RGD
    Primary source
    RGD:1311897
    See related
    EnsemblRapid:ENSRNOG00000005857 AllianceGenome:RGD:1311897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311897
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRC3B (leucine rich repeat containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 51.7), Heart (RPKM 51.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc3b in Genome Data Viewer
    Location:
    15p16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (12404309..12481618)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (9973580..10050891)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (11221161..11299563)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108352885 Neighboring gene protein phosphatase 2, regulatory subunit B', gamma, pseudogene 1 Neighboring gene uncharacterized LOC120097104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Odor-evoked gene regulation and visualization in olfactory receptor neurons. Bennett MK, et al. Mol Cell Neurosci, 2010 Apr. PMID 20080187, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lrrc3b gene expression in olfactory receptor neurons was regulated more than 10-fold by odorant activity.
      Title: Odor-evoked gene regulation and visualization in olfactory receptor neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399495.1 → NP_001386424.1  leucine-rich repeat-containing protein 3B precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K053, D4A9I7
      Related
      ENSRNOP00000085779.1, ENSRNOT00000094588.2
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      12404309..12481618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599839.3 → XP_017455328.1  leucine-rich repeat-containing protein 3B isoform X1

      UniProtKB/TrEMBL
      A6K053, D4A9I7
      Related
      ENSRNOP00000102741.1, ENSRNOT00000138177.1
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat

    2. XM_006251719.5 → XP_006251781.1  leucine-rich repeat-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_006251781.1

      UniProtKB/TrEMBL
      A6K053, D4A9I7
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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