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    Acam Androcam [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acamprovided by FlyBase
    Official Full Name
    Androcamprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011273
    Locus tag
    Dmel_CG17769
    See related
    AllianceGenome:FB:FBgn0011273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACaM; And; CalB; Camr97A; CG17769; Dmel\CG17769
    Summary
    Enables myosin VI head/neck binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in cytoplasm; investment cone; and nucleus. Part of myosin VI complex. Is expressed in organism and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acam in Genome Data Viewer
    Location:
    96F3-96F3; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25811911..25813134)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21637633..21638856)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45652 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44949

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR chemical shift assignments for androcam, a testis-specific myosin VI light chain in D. melanogaster. Joshi MK, et al. Biomol NMR Assign, 2013 Oct. PMID 22706933
    2. ¹H, ¹⁵N and ¹³C chemical shifts of the D. melanogaster myosin VI light chain androcam in high calcium. Joshi MK, et al. Biomol NMR Assign, 2013 Oct. PMID 22706934
    3. Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila. Martin SR, et al. Protein Sci, 1999 Nov. PMID 10595548, Free PMC Article
    4. Androcam, a Drosophila calmodulin-related protein, is expressed specifically in the testis and decorates loop kl-3 of the Y chromosome. Lu AQ, et al. Mech Dev, 2000 Jun. PMID 10842068
    5. The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster. Kuklin EA, et al. J Neurosci, 2017 Nov 1. PMID 28954869, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM.
      Title: Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM.
    2. Drosophila CaMKII-null mutants remain viable throughout development, but the long 3'-untranslated region is necessary for modulating spontaneous neurotransmission.
      Title: The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster.
    3. The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin.
      Title: Structure of androcam supports specialized interactions with myosin VI.
    4. acts as a myosin VI light chain in the Drosophila testis and may alter the regulation of myosin VI in this tissue
      Title: Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin VI head/neck binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament-based movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in investment cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin VI complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    androcam
    Names
    Acam-PA
    Acam-PB
    CG17769-PA
    CG17769-PB
    Calmodulin-related 97A
    androcalmodulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25811911..25813134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170266.1 → NP_001163737.1  androcam, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163737.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JIY2, P49258, Q9VBL9
      UniProtKB/TrEMBL
      A0A1B2AJ49
      Conserved Domains (1) summary
      PTZ00184
      Location:3 → 148
      PTZ00184; calmodulin; Provisional

    2. NM_057640.3 → NP_476988.1  androcam, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JIY2, P49258, Q9VBL9
      UniProtKB/TrEMBL
      A0A1B2AJ49
      Related
      FBpp0084278
      Conserved Domains (1) summary
      PTZ00184
      Location:3 → 148
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49258.2 P49258

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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