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    Mthfs methenyltetrahydrofolate synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mthfsprovided by RGD
    Official Full Name
    methenyltetrahydrofolate synthetaseprovided by RGD
    Primary source
    RGD:1306876
    See related
    EnsemblRapid:ENSRNOG00000013229 AllianceGenome:RGD:1306876
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in dicarboxylic acid metabolic process; folic acid-containing compound biosynthetic process; and tetrahydrofolate interconversion. Predicted to be located in cytosol and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 58.5), Liver (RPKM 57.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mthfs in Genome Data Viewer
    Location:
    8q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (98609410..98681901)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89729498..89801998)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (96564877..96614386)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD50 Neighboring gene tripartite motif-containing 43A Neighboring gene similar to RIKEN cDNA 4930579C12 gene Neighboring gene ribosomal protein S16, pseudogene 7 Neighboring gene BCL2-related protein A1 Neighboring gene uncharacterized LOC120094223 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Anguera MC, et al. J Biol Chem, 2003 Aug 8. PMID 12764149
    2. Identification and characterization of human mitochondrial methenyltetrahydrofolate synthetase activity. Bertrand R, et al. Biochim Biophys Acta, 1995 May 12. PMID 7766710
    3. Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues. Wu D, et al. Cancer Res, 2009 Sep 15. PMID 19738041
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95139

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-formyltetrahydrofolate cyclo-ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in folic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-formyltetrahydrofolate cyclo-ligase
    Names
    5, 10-methenyltetrahydrofolate synthetase
    5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
    NP_001009349.1
    XP_038937095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009349.1 → NP_001009349.1  5-formyltetrahydrofolate cyclo-ligase

      See identical proteins and their annotated locations for NP_001009349.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087144
      UniProtKB/TrEMBL
      A6I201, F7FDD4, Q5M9F6
      Related
      ENSRNOP00000017879.4, ENSRNOT00000017879.8
      Conserved Domains (1) summary
      pfam01812
      Location:10 → 198
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      98609410..98681901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081167.2 → XP_038937095.1  5-formyltetrahydrofolate cyclo-ligase isoform X1

      Conserved Domains (1) summary
      cl00360
      Location:10 → 128
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    Nucleotide Protein Strain
    Heading Accession and Version

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