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    CG5569 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5569provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034919
    Locus tag
    Dmel_CG5569
    See related
    AllianceGenome:FB:FBgn0034919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD18780; Dmel\CG5569; dNDUFAF3
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Is active in mitochondrion. Is expressed in adult head and organism. Used to study nuclear type mitochondrial complex I deficiency 18. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5569 in Genome Data Viewer
    Location:
    60A5-60A5; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23865414..23866654)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19752937..19754177)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TAR DNA-binding protein-43 homolog Neighboring gene Ceramide phosphoethanolamine synthase Neighboring gene Mitochondrial trifunctional protein beta subunit Neighboring gene ken and barbie Neighboring gene Transmembrane 4 superfamily Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article
    2. IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system. Murari A, et al. Sci Adv, 2022 May 13. PMID 35544578, Free PMC Article
    3. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5569-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23865414..23866654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137996.4 → NP_611840.1  uncharacterized protein Dmel_CG5569 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1H9
      Related
      FBpp0072037
      Conserved Domains (1) summary
      cd05125
      Location:57 → 172
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1H9 Q9W1H9

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