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    Pacrg parkin coregulated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pacrgprovided by RGD
    Official Full Name
    parkin coregulatedprovided by RGD
    Primary source
    RGD:1561027
    See related
    EnsemblRapid:ENSRNOG00000068261 AllianceGenome:RGD:1561027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561027
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; heat shock protein binding activity; and ubiquitin protein ligase binding activity. Predicted to act upstream of or within protein localization and spermatid development. Predicted to be located in several cellular components, including cell body; microtubule cytoskeleton; and sperm midpiece. Predicted to be active in axonemal B tubule inner sheath. Orthologous to human PACRG (parkin coregulated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 482.1) and Lung (RPKM 29.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pacrg in Genome Data Viewer
    Location:
    1q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (52430390..52853272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (49882671..50305564)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (50070273..50491323)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC134482720 Neighboring gene uncharacterized LOC120100098 Neighboring gene colon adenocarcinoma hypermethylated Neighboring gene QKI, KH domain containing RNA binding

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function. Wilson GR, et al. Neurosci Lett, 2009 Aug 21. PMID 19463890
    2. Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Lorenzetti D, et al. Proc Natl Acad Sci U S A, 2004 Jun 1. PMID 15148410, Free PMC Article
    3. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Imai Y, et al. J Biol Chem, 2003 Dec 19. PMID 14532270
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    parkin coregulated gene protein
    Names
    Park2 co-regulated
    parkin co-regulated gene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389238.1 → NP_001376167.1  parkin coregulated gene protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AHI9, A0A8I6AVE7, A6KJZ9
      Related
      ENSRNOP00000093391.2, ENSRNOT00000101907.2
      Conserved Domains (1) summary
      pfam10274
      Location:70 → 253
      ParcG; Parkin co-regulated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      52430390..52853272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086904.2 → XP_038942832.1  parkin coregulated gene protein isoform X1

      UniProtKB/TrEMBL
      A6KK00
      Conserved Domains (1) summary
      pfam10274
      Location:1 → 135
      ParcG; Parkin co-regulated protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077677.1: Suppressed sequence

      Description
      NM_001077677.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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