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    Cog2 component of oligomeric golgi complex 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690961, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cog2provided by RGD
    Official Full Name
    component of oligomeric golgi complex 2provided by RGD
    Primary source
    RGD:1589822
    See related
    EnsemblRapid:ENSRNOG00000018228 AllianceGenome:RGD:1589822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Orthologous to human COG2 (component of oligomeric golgi complex 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 96.7), Thymus (RPKM 89.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cog2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69391305..69430072)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52493901..52532667)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57286955..57322853)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 5 Neighboring gene uncharacterized LOC108348970 Neighboring gene angiotensinogen Neighboring gene calpain 9 Neighboring gene similar to human chromosome 1 open reading frame 198

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. Podos SD, et al. J Cell Biol, 1994 Nov. PMID 7962052, Free PMC Article
    2. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar D, et al. J Cell Biol, 2002 Apr 29. PMID 11980916, Free PMC Article
    3. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. Loh E, et al. J Biol Chem, 2002 Jun 14. PMID 11929878
    4. The binary interacting network of the conserved oligomeric Golgi tethering complex. Loh E, et al. J Biol Chem, 2004 Jun 4. PMID 15047703
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110494.1 → NP_001103964.1  conserved oligomeric Golgi complex subunit 2

      See identical proteins and their annotated locations for NP_001103964.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474054
      UniProtKB/TrEMBL
      A6KJ08, D3ZT01
      Related
      ENSRNOP00000054881.2, ENSRNOT00000058074.4
      Conserved Domains (2) summary
      pfam06148
      Location:15 → 147
      COG2; COG (conserved oligomeric Golgi) complex component, COG2
      pfam12022
      Location:566 → 691
      DUF3510; Domain of unknown function (DUF3510)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69391305..69430072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255816.5 → XP_006255878.1  conserved oligomeric Golgi complex subunit 2 isoform X1

      Conserved Domains (2) summary
      pfam06148
      Location:15 → 147
      COG2; COG (conserved oligomeric Golgi) complex component, COG2
      pfam12022
      Location:566 → 691
      DUF3510; Domain of unknown function (DUF3510)

    2. XM_063278299.1 → XP_063134369.1  conserved oligomeric Golgi complex subunit 2 isoform X2

    RNA

    1. XR_001842215.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous