Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk2n1provided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase II inhibitor 1provided by RGD
Primary source: RGD:708430
See related: AllianceGenome:RGD:708430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of systemic arterial blood pressure. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1717.2), Kidney (RPKM 271.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (155958116..155959897)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (150674819..150676600)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (156876706..156878486)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMKII inhibitor 1 (CaMK2N1) mRNA is upregulated following LTP induction in hippocampal slices.
Title: CaMKII inhibitor 1 (CaMK2N1) mRNA is upregulated following LTP induction in hippocampal slices.
we employed optogenetic technique to selectively activate the excitatory neurons expressing CaMKIIalpha in the VTA region and induced a higher locomotor activity for free behaving rats
Title: Optogenetic activation of the excitatory neurons expressing CaMKIIα in the ventral tegmental area upregulates the locomotor activity of free behaving rats.
CaMKIIN proteins are associated with cell-wide homeostatic regulation, preventing saturation of LTP mechanisms in specific groups of synapses.
Title: On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IC Inferred by Curator more info	PubMed
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase II inhibitor 1

Names: CaM-kinase II inhibitor alpha; caM-KIINalpha; caMKIINalpha; calcium/calmodulin-dependent protein kinase II inhibitor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173337.1 → NP_775459.1 calcium/calmodulin-dependent protein kinase II inhibitor 1

See identical proteins and their annotated locations for NP_775459.1

Status: PROVISIONAL

Source sequence(s)

AF271156

UniProtKB/Swiss-Prot

Q9JI15

UniProtKB/TrEMBL

A6ITI0

Conserved Domains (1) summary

pfam15170
Location:1 → 78

CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor