Rnf123 ring finger protein 123 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rnf123provided by RGD
Full Name: ring finger protein 123provided by RGD
Primary source: RGD:2301394
See related: EnsemblRapid:ENSRNOG00000033378 AllianceGenome:RGD:2301394
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein maturation; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 167.6), Muscle (RPKM 112.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117618776..117646400, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108740176..108768177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116829050..116857050, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bax can be a novel target for the antiapoptotic effects of KPC1 on I/R-induced cardiomyocyte apoptosis and render mechanistic penetration into at least a subset of the mitochondrial effects of KPC1.
Title: KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation.
results suggest that KPC1 (Kip1 ubiquitylation-promoting complex 1) is related to the down-regulation of p27(kip1); this event may be involved in the proliferation of astrocytes after spinal cord injury
Title: KPC1 expression and essential role after acute spinal cord injury in adult rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129768 (e-PCR)
- UniSTS:213060

BE119447 (e-PCR)
- UniSTS:249191

Amigo3 (e-PCR), detects polymorphism
- UniSTS:525536

RH139593 (e-PCR)
- UniSTS:221677

MARC_17265-17266:1024683815:1 (e-PCR)
- UniSTS:268271

MARC_17265-17266:1032372309:1 (e-PCR)
- UniSTS:268271

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein maturation	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF123

Names: RING-type E3 ubiquitin transferase RNF123; kip1 ubiquitination-promoting complex protein 1

NP_001178509.1

EC 2.3.2.27

XP_006243753.1

EC 2.3.2.27

XP_006243755.1

EC 2.3.2.27

XP_006243757.1

EC 2.3.2.27

XP_063120775.1

EC 2.3.2.27

XP_063120776.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191580.1 → NP_001178509.1 E3 ubiquitin-protein ligase RNF123

See identical proteins and their annotated locations for NP_001178509.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

D3ZXK7

Related

ENSRNOP00000041545.3, ENSRNOT00000043825.6

Conserved Domains (2) summary

pfam13920
Location:1248 → 1296

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cd12882
Location:121 → 248

SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117618776..117646400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243695.5 → XP_006243757.1 E3 ubiquitin-protein ligase RNF123 isoform X1

See identical proteins and their annotated locations for XP_006243757.1

UniProtKB/Swiss-Prot

D3ZXK7

Conserved Domains (2) summary

pfam13920
Location:1248 → 1296

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cd12882
Location:121 → 248

SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
XM_006243691.5 → XP_006243753.1 E3 ubiquitin-protein ligase RNF123 isoform X1

See identical proteins and their annotated locations for XP_006243753.1

UniProtKB/Swiss-Prot

D3ZXK7

Conserved Domains (2) summary

pfam13920
Location:1248 → 1296

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cd12882
Location:121 → 248

SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
XM_063264705.1 → XP_063120775.1 E3 ubiquitin-protein ligase RNF123 isoform X2

Related

ENSRNOP00000110165.1, ENSRNOT00000159612.1
XM_006243693.5 → XP_006243755.1 E3 ubiquitin-protein ligase RNF123 isoform X1

See identical proteins and their annotated locations for XP_006243755.1

UniProtKB/Swiss-Prot

D3ZXK7

Conserved Domains (2) summary

pfam13920
Location:1248 → 1296

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cd12882
Location:121 → 248

SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
XM_063264706.1 → XP_063120776.1 E3 ubiquitin-protein ligase RNF123 isoform X3