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    Ung uracil-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304577, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ungprovided by RGD
    Official Full Name
    uracil-DNA glycosylaseprovided by RGD
    Primary source
    RGD:1307200
    See related
    AllianceGenome:RGD:1307200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables uracil DNA N-glycosylase activity. Involved in base-excision repair and negative regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 105.3), Kidney (RPKM 99.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ung in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48145838..48154789, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42485276..42494217, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48246593..48255547, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene forkhead box N4 Neighboring gene uncharacterized LOC134481305 Neighboring gene acetyl-CoA carboxylase beta Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene ubiquitin specific peptidase 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of uracil-DNA glycosylase induces neuronal apoptosis. Kruman II, et al. J Biol Chem, 2004 Oct 15. PMID 15297456
    2. Highly efficient base excision repair (BER) in human and rat male germ cells. Olsen AK, et al. Nucleic Acids Res, 2001 Apr 15. PMID 11292851, Free PMC Article
    3. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Imai K, et al. Nat Immunol, 2003 Oct. PMID 12958596
    4. Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nilsen H, et al. Nucleic Acids Res, 2000 Jun 15. PMID 10871356, Free PMC Article
    5. Expression and activity of the DNA repair enzyme uracil DNA glycosylase during organogenesis in the rat conceptus and following methotrexate exposure in vitro. Vinson RK, et al. Biochem Pharmacol, 2002 Aug 15. PMID 12167490

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108922

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation via deaminated base removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, AP site formation via deaminated base removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uracil-DNA glycosylase
    NP_001013142.1
    XP_008767558.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013124.1 → NP_001013142.1  uracil-DNA glycosylase

      See identical proteins and their annotated locations for NP_001013142.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091211
      UniProtKB/TrEMBL
      F7F2G1, Q5BK44
      Conserved Domains (1) summary
      TIGR00628
      Location:86 → 295
      ung; uracil-DNA glycosylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48145838..48154789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769336.4 → XP_008767558.2  uracil-DNA glycosylase isoform X1

      UniProtKB/TrEMBL
      A0A8J8YLI4, A6J209
      Conserved Domains (2) summary
      TIGR00628
      Location:93 → 302
      ung; uracil-DNA glycosylase
      cd10027
      Location:149 → 153
      UDG-F1-like; motif A [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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