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    CG17633 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17633provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032144
    Locus tag
    Dmel_CG17633
    See related
    AllianceGenome:FB:FBgn0032144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17633
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA1 (carboxypeptidase A1); CPA2 (carboxypeptidase A2); and CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17633 in Genome Data Viewer
    Location:
    30C8-30C8; 2-36 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9769060..9770409)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9769060..9770409)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uninitiated Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein Neighboring gene pickpocket 11 Neighboring gene pickpocket 16 Neighboring gene Inositol 1,4,5-triphosphate kinase 1 Neighboring gene hairpin RNA:CR18854

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Okumura T, et al. Gene Expr Patterns, 2007 Jan. PMID 16914392
    2. Drosophila melanogaster males respond differently at the behavioural and genome-wide levels to Drosophila melanogaster and Drosophila simulans females. Ellis LL, et al. J Evol Biol, 2009 Nov. PMID 19765174
    3. Fitness Analysis and Transcriptome Profiling Following Repeated Mild Heat Stress of Varying Frequency in Drosophilamelanogaster Females. Gruntenko NE, et al. Biology (Basel), 2021 Dec 14. PMID 34943239, Free PMC Article
    4. Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. Icreverzi A, et al. Aging Cell, 2015 Oct. PMID 26219626, Free PMC Article
    5. SSCP analysis of cDNA markers provides a dense linkage map of the Aedes aegypti genome. Fulton RE, et al. Genetics, 2001 Jun. PMID 11404335, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17633-PA
    NP_609310.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9769060..9770409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135466.4 → NP_609310.2  uncharacterized protein Dmel_CG17633 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609310.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZP6, Q9VL86
      UniProtKB/TrEMBL
      B5X0K4
      Related
      FBpp0079464
      Conserved Domains (3) summary
      cd03860
      Location:125 → 423
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      COG2866
      Location:7 → 374
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]
      pfam02244
      Location:34 → 105
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL86.1 Q9VL86

    Gene LinkOut

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