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    Arv1 ARV1 homolog, fatty acid homeostasis modulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arv1provided by RGD
    Official Full Name
    ARV1 homolog, fatty acid homeostasis modulatorprovided by RGD
    Primary source
    RGD:1310264
    See related
    AllianceGenome:RGD:1310264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310264
    Summary
    Predicted to be involved in several processes, including intracellular sterol transport; regulation of intracellular cholesterol transport; and regulation of plasma membrane sterol distribution. Predicted to act upstream of or within bile acid metabolic process; cholesterol transport; and regulation of cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 37.2), Spleen (RPKM 29.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arv1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69589728..69601547)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52692337..52704156)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57484720..57496539)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098646 Neighboring gene tetratricopeptide repeat domain 13 Neighboring gene family with sequence similarity 89, member A Neighboring gene transfer RNA alanine (anticodon AGC) 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. Tong F, et al. J Biol Chem, 2010 Oct 29. PMID 20663892, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of plasma membrane sterol distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein ARV1
    Names
    ARV1 fatty acid homeostatsis modulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106197.2 → NP_001099667.1  protein ARV1 isoform 1

      See identical proteins and their annotated locations for NP_001099667.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6KJ16, D3ZTJ1
      Conserved Domains (1) summary
      pfam04161
      Location:29 → 218
      Arv1; Arv1-like family

    2. NM_001434508.1 → NP_001421437.1  protein ARV1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    3. NM_001434509.1 → NP_001421438.1  protein ARV1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    4. NM_001434510.1 → NP_001421439.1  protein ARV1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69589728..69601547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772606.4 → XP_008770828.1  protein ARV1 isoform X1

      Conserved Domains (1) summary
      pfam04161
      Location:29 → 145
      Arv1; Arv1-like family

    2. XM_063277956.1 → XP_063134026.1  protein ARV1 isoform X2

    3. XM_063277957.1 → XP_063134027.1  protein ARV1 isoform X4

    4. XM_039097668.2 → XP_038953596.1  protein ARV1 isoform X3

      Conserved Domains (1) summary
      cl21705
      Location:2 → 42
      Arv1; Arv1-like family

    5. XM_039097667.2 → XP_038953595.1  protein ARV1 isoform X3

      Conserved Domains (1) summary
      cl21705
      Location:2 → 42
      Arv1; Arv1-like family
    Nucleotide Protein Strain
    Heading Accession and Version

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