Sec23b Sec23 homolog B, COPII coat complex component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sec23bprovided by RGD
Official Full Name: Sec23 homolog B, COPII coat complex componentprovided by RGD
Primary source: RGD:1310699
See related: EnsemblRapid:ENSRNOG00000008411 AllianceGenome:RGD:1310699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Cowden syndrome 7 and congenital dyserythropoietic anemia type II. Orthologous to human SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 187.2), Kidney (RPKM 183.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (152392340..152434813)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (131939011..131981489)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (138715118..138757111)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein transport protein Sec23B

Names: Sec23 homolog B, coat complex II component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277235.1 → NP_001264164.1 protein transport protein Sec23B

See identical proteins and their annotated locations for NP_001264164.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZKS5, D3ZCT7

Related

ENSRNOP00000062590.3, ENSRNOT00000064723.5

Conserved Domains (1) summary

PLN00162
Location:12 → 765

PLN00162; transport protein sec23; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

152392340..152434813

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235126.5 → XP_006235188.1 protein transport protein Sec23B isoform X1

See identical proteins and their annotated locations for XP_006235188.1

UniProtKB/TrEMBL

A0A8I5ZKS5, D3ZCT7

Related

ENSRNOP00000078374.2, ENSRNOT00000095527.2

Conserved Domains (1) summary

PLN00162
Location:12 → 765

PLN00162; transport protein sec23; Provisional
XM_063284169.1 → XP_063140239.1 protein transport protein Sec23B isoform X1

UniProtKB/TrEMBL

D3ZCT7
XM_063284168.1 → XP_063140238.1 protein transport protein Sec23B isoform X1

UniProtKB/TrEMBL

D3ZCT7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108593.1: Suppressed sequence

Description

NM_001108593.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.