Sidt2 SID1 transmembrane family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sidt2provided by RGD
Official Full Name: SID1 transmembrane family, member 2provided by RGD
Primary source: RGD:1308311
See related: EnsemblRapid:ENSRNOG00000017871 AllianceGenome:RGD:1308311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308311
Summary: Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Predicted to be involved in RNA catabolic process and RNA transport. Predicted to act upstream of or within several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; type B pancreatic cell development; and type B pancreatic cell proliferation. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome and plasma membrane. Orthologous to human SIDT2 (SID1 transmembrane family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 364.3), Kidney (RPKM 196.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55129091..55146446, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46232379..46248913, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50230335..50246979, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sdit2 may play a vital role in the regulation of insulin secretion via two SNARE proteins synap1 and syanp3.
Title: Lysosomal integral membrane protein Sidt2 plays a vital role in insulin secretion.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134381 (e-PCR)
- UniSTS:217663

AI747451 (e-PCR)
- UniSTS:163457

RH136962 (e-PCR)
- UniSTS:219051

Pafah1b2 (e-PCR), detects polymorphism
- UniSTS:144115

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AP-1 adaptor complex binding	IEA Inferred from Electronic Annotation more info
enables AP-1 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables AP-1 adaptor complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables AP-2 adaptor complex binding	IEA Inferred from Electronic Annotation more info
enables AP-2 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables AP-2 adaptor complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA transport	IEA Inferred from Electronic Annotation more info
involved_in RNA transport	ISO Inferred from Sequence Orthology more info
involved_in RNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SID1 transmembrane family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108142.2 → NP_001101612.2 SID1 transmembrane family member 2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0A0MP80

Related

ENSRNOP00000024239.5, ENSRNOT00000024240.9
NM_001429669.1 → NP_001416598.1 SID1 transmembrane family member 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0A0MP80
NM_001429670.1 → NP_001416599.1 SID1 transmembrane family member 2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

D3ZEH5, D3ZSU1

UniProtKB/TrEMBL

A0A0A0MP80
NM_001429671.1 → NP_001416600.1 SID1 transmembrane family member 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001429672.1 → NP_001416601.1 SID1 transmembrane family member 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001429673.1 → NP_001416602.1 SID1 transmembrane family member 2 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

55129091..55146446 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242943.5 → XP_006243005.1 SID1 transmembrane family member 2 isoform X5

Conserved Domains (2) summary

pfam13965
Location:298 → 958

SID-1_RNA_chan; dsRNA-gated channel SID-1

pfam15730
Location:44 → 97

DUF4680; Domain of unknown function (DUF4680)
XM_006242942.5 → XP_006243004.1 SID1 transmembrane family member 2 isoform X4

UniProtKB/TrEMBL

A0A0A0MP80, A0A8L2QIN5

Related

ENSRNOP00000035750.3, ENSRNOT00000035310.5

Conserved Domains (2) summary

pfam13965
Location:298 → 962

SID-1_RNA_chan; dsRNA-gated channel SID-1

pfam15730
Location:44 → 97

DUF4680; Domain of unknown function (DUF4680)
XM_006242941.5 → XP_006243003.1 SID1 transmembrane family member 2 isoform X3

UniProtKB/TrEMBL

A0A0A0MP80, A0A8I6ADA5

Related

ENSRNOP00000092236.1, ENSRNOT00000111154.2

Conserved Domains (2) summary

pfam13965
Location:298 → 983

SID-1_RNA_chan; dsRNA-gated channel SID-1

pfam15730
Location:44 → 97

DUF4680; Domain of unknown function (DUF4680)
XM_039081438.2 → XP_038937366.1 SID1 transmembrane family member 2 isoform X2

Conserved Domains (1) summary

pfam13965
Location:296 → 987

SID-1_RNA_chan; dsRNA-gated channel SID-1
XM_039081436.2 → XP_038937364.1 SID1 transmembrane family member 2 isoform X1

UniProtKB/TrEMBL

A0A0A0MP80, A6J466

Conserved Domains (1) summary

pfam13965
Location:296 → 1008

SID-1_RNA_chan; dsRNA-gated channel SID-1
XM_063265438.1 → XP_063121508.1 SID1 transmembrane family member 2 isoform X6