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    Eif4g2 eukaryotic translation initiation factor 4, gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4g2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 2provided by RGD
    Primary source
    RGD:1305294
    See related
    EnsemblRapid:ENSRNOG00000017158 AllianceGenome:RGD:1305294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse and rat. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Kidney (RPKM 1924.4), Thymus (RPKM 1372.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4g2 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (174616102..174628252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (165181433..165193583, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (175883362..175895510, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene small nucleolar RNA, C/D box 97 Neighboring gene zinc finger BED-type containing 5 like, pseudogene 1 Neighboring gene uncharacterized LOC100911864

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. Srivastava T, et al. J Neurosci, 2012 Apr 18. PMID 22514323, Free PMC Article
    2. Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy. Sangaralingham SJ, et al. Mol Cell Biochem, 2003 Mar. PMID 12708758
    3. Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons. Kar AN, et al. J Neurosci, 2013 Apr 24. PMID 23616526, Free PMC Article
    4. Developmental regulation of the translational repressor NAT1 during cardiac development. Pak BJ, et al. J Mol Cell Cardiol, 1999 Sep. PMID 10471355
    5. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Henis-Korenblit S, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11943866, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Local protein synthesis was found to be regulated by Eif4g2 (and Eif2b2) in the axon.
      Title: Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
    2. At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.
      Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017374.2 → NP_001017374.2  eukaryotic translation initiation factor 4 gamma 2

      Status: REVIEWED

      Source sequence(s)
      AB256044, BC099117, CB730161
      UniProtKB/TrEMBL
      A0A8I6A1T4
      Related
      ENSRNOP00000062967.4, ENSRNOT00000064535.4
      Conserved Domains (3) summary
      cd11559
      Location:739 → 875
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:543 → 656
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      174616102..174628252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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