Slc18a1 solute carrier family 18 member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc18a1provided by RGD
Official Full Name: solute carrier family 18 member A1provided by RGD
Primary source: RGD:3693
See related: EnsemblRapid:ENSRNOG00000011992 AllianceGenome:RGD:3693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CGAT; VMAT-1
Summary: Enables enzyme binding activity; monoamine:proton antiporter activity; and serotonin:sodium:chloride symporter activity. Involved in several processes, including cellular response to lithium ion; positive regulation of dopamine secretion; and serotonin uptake. Predicted to be located in endoplasmic reticulum membrane and secretory granule membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 81.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (25408485..25453786)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (20653268..20687051)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (22358646..22395183)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body.
Title: Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body.
Transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia.
Title: Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury.
First step toward the comprehension of the role of the VMAT-1 transporter in renal dopamine handling and its involvement in pathological situations.
Title: Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoamine:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables monoamine:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables serotonin:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lithium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chromaffin granule amine transporter

Names: VAT1; VMAT1; solute carrier family 18 (vesicular monoamine transporter), member 1; solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 member 1; solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter); vesicular amine transporter 1; vesicular monoamine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013152.2 → NP_037284.2 chromaffin granule amine transporter

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016, M97380

UniProtKB/Swiss-Prot

Q01818

UniProtKB/TrEMBL

F1LSA7

Related

ENSRNOP00000016193.2, ENSRNOT00000016193.5

Conserved Domains (3) summary

cd06174
Location:299 → 475

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00880
Location:137 → 278

2_A_01_02; Multidrug resistance protein

pfam07690
Location:136 → 442

MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

25408485..25453786

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275099.1 → XP_063131169.1 chromaffin granule amine transporter isoform X1

UniProtKB/TrEMBL

F1LSA7
XM_039094220.2 → XP_038950148.1 chromaffin granule amine transporter isoform X2

UniProtKB/Swiss-Prot

Q01818

Conserved Domains (1) summary

cd17384
Location:34 → 424

MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily
XM_063275103.1 → XP_063131173.1 chromaffin granule amine transporter isoform X3
XM_063275104.1 → XP_063131174.1 chromaffin granule amine transporter isoform X4
XM_063275101.1 → XP_063131171.1 chromaffin granule amine transporter isoform X1

UniProtKB/TrEMBL

F1LSA7
XM_063275102.1 → XP_063131172.1 chromaffin granule amine transporter isoform X1

UniProtKB/TrEMBL

F1LSA7
XM_063275100.1 → XP_063131170.1 chromaffin granule amine transporter isoform X1

UniProtKB/TrEMBL

F1LSA7