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    Ero1a endoplasmic reticulum oxidoreductase 1 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171562, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ero1aprovided by RGD
    Official Full Name
    endoplasmic reticulum oxidoreductase 1 alphaprovided by RGD
    Primary source
    RGD:621713
    See related
    EnsemblRapid:ENSRNOG00000006462 AllianceGenome:RGD:621713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ero1l
    Summary
    Predicted to enable protein-disulfide reductase activity. Involved in cellular response to hypoxia. Located in dendrite. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 96.6), Brain (RPKM 96.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ero1a in Genome Data Viewer
    Location:
    15p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (20974771..21010170, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18495037..18530440, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19619947..19655381, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 like 6 Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2, pseudogene 1 Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene farnesyl diphosphate synthase pseudogene Neighboring gene serine/threonine/tyrosine interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein maturation by protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ERO1-like protein alpha
    Names
    ERO1-L
    ERO1-L-alpha
    endoplasmic oxidoreductin-1-like protein
    endoplasmic reticulum oxidoreductase alpha
    endoplasmic reticulum oxidoreductin-1-like protein
    global ischemia-induced protein 11
    oxidoreductin-1-L-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433862.1NP_001420791.1  ERO1-like protein alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    2. NM_138528.2NP_612537.2  ERO1-like protein alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      Related
      ENSRNOP00000094430.1, ENSRNOT00000116811.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      20974771..21010170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)