Acr acrosin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acrprovided by RGD
Official Full Name: acrosinprovided by RGD
Primary source: RGD:2024
See related: EnsemblRapid:ENSRNOG00000029762 AllianceGenome:RGD:2024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acro
Summary: Predicted to enable amidase activity; monosaccharide binding activity; and serine-type endopeptidase activity. Involved in acrosome matrix dispersal; penetration of zona pellucida; and response to steroid hormone. Located in Golgi-associated vesicle and acrosomal vesicle. Human ortholog(s) of this gene implicated in spermatogenic failure 87. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 51.0), Lung (RPKM 4.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122517910..122524110)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120636581..120644474)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130541320..130548356)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that that acrosin disrupted spermatozoa possessed an equal ability to penetrate the zona pellucida with wild-type spermatozoa, but the cumulus cell dispersal was slower compared to wild-type and heterozygous spermatozoa.
Title: A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	ISO Inferred from Sequence Orthology more info
enables D-mannose binding	ISS Inferred from Sequence or Structural Similarity more info
enables amidase activity	ISO Inferred from Sequence Orthology more info
enables amidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fucose binding	ISO Inferred from Sequence Orthology more info
enables fucose binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acrosome matrix dispersal	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info
involved_in acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in acrosome reaction	ISS Inferred from Sequence or Structural Similarity more info
involved_in acrosome reaction	TAS Traceable Author Statement more info	PubMed
involved_in activation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within penetration of zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in penetration of zona pellucida	TAS Traceable Author Statement more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in single fertilization	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal matrix	TAS Traceable Author Statement more info	PubMed
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acrosin

Names: acrosin prepropeptide

NP_036622.2

EC 3.4.21.10

XP_006242240.1

EC 3.4.21.10

XP_017450144.1

EC 3.4.21.10

XP_017450145.1

EC 3.4.21.10

XP_038934318.2

EC 3.4.21.10

XP_038934319.1

EC 3.4.21.10

XP_063119043.1

EC 3.4.21.10

XP_063119044.1

EC 3.4.21.10

XP_063119045.1

EC 3.4.21.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012490.2 → NP_036622.2 acrosin precursor

See identical proteins and their annotated locations for NP_036622.2

Status: VALIDATED

Source sequence(s)

BC097345

UniProtKB/Swiss-Prot

P29293, Q4QR89, Q9QWF2

UniProtKB/TrEMBL

A6K7N9

Related

ENSRNOP00000046900.3, ENSRNOT00000045647.5

Conserved Domains (1) summary

smart00020
Location:42 → 286

Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122517910..122524110

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262975.1 → XP_063119045.1 acrosin isoform X5
XM_006242178.5 → XP_006242240.1 acrosin isoform X3

Conserved Domains (2) summary

smart00020
Location:42 → 238

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:43 → 238

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063262974.1 → XP_063119044.1 acrosin isoform X4
XM_017594655.3 → XP_017450144.1 acrosin isoform X2

Conserved Domains (1) summary

smart00020
Location:1 → 230

Tryp_SPc; Trypsin-like serine protease
XM_017594656.3 → XP_017450145.1 acrosin isoform X2

Conserved Domains (1) summary

smart00020
Location:1 → 230

Tryp_SPc; Trypsin-like serine protease
XM_063262973.1 → XP_063119043.1 acrosin isoform X2
XM_039078390.2 → XP_038934318.2 acrosin isoform X1
XM_039078391.2 → XP_038934319.1 acrosin isoform X6

Conserved Domains (1) summary

cd00190
Location:1 → 92

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...