Slc7a5 solute carrier family 7 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a5provided by RGD
Official Full Name: solute carrier family 7 member 5provided by RGD
Primary source: RGD:620639
See related: EnsemblRapid:ENSRNOG00000018824 AllianceGenome:RGD:620639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: E16; TA1; LAT-1
Summary: Enables amino acid transmembrane transporter activity. Involved in several processes, including branched-chain amino acid transport; cellular response to L-arginine; and liver regeneration. Located in basolateral plasma membrane and external side of apical plasma membrane. Used to study high grade glioma. Biomarker of hepatocellular carcinoma and transitional cell carcinoma. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 109.2), Brain (RPKM 87.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (66843808..66872412, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (49935220..49963823, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (54693959..54722563, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain.
Title: Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain.
Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.
Title: Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.
Study results imply that LAT1 at the inner and outer blood-retinal barrier takes part in gabapentin transport between the circulating blood and retina.
Title: Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin.
Immediately after the exercise, expression of mRNAs encoding L-type amino acid transporter 1 (LAT1) and CD98 was induced in the gastrocnemius, soleus, and extensor digitorum longus muscles
Title: Induction of amino acid transporters expression by endurance exercise in rat skeletal muscle.
is concluded that the spontaneous hypertensive rat kidney overexpress LAT1/4F2hc units which display low affinity for L-leucine transport.
Title: Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-tryptophan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-tryptophan transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISS Inferred from Sequence or Structural Similarity more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-amino acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in L-tryptophan transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-tryptophan transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amino acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in isoleucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in isoleucine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in methionine transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in phenylalanine transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-leucine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info
involved_in tyrosine transport	ISO Inferred from Sequence Orthology more info
involved_in valine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of amino acid transport complex	ISO Inferred from Sequence Orthology more info
part_of amino acid transport complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 1

Names: 4F2 LC; 4F2 light chain; 4F2LC; L-type amino acid transporter 1; TA1/LAT-1/CD98 light chain region; integral membrane protein E16; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; tumor-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.