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    Wipf1 WAS/WASL interacting protein family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117538, updated on 9-Dec-2024

    Summary

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    Symbol
    Wipf1provided by RGD
    Full Name
    WAS/WASL interacting protein family, member 1provided by RGD
    Primary source
    RGD:620887
    See related
    EnsemblRapid:ENSRNOG00000018406 AllianceGenome:RGD:620887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wip; Waspip
    Summary
    Predicted to enable SH3 domain binding activity and protein folding chaperone. Involved in actin cytoskeleton organization and positive regulation of protein export from nucleus. Located in actin filament. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 247.7), Thymus (RPKM 181.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wipf1 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78721486..78824199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58314521..58416668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60150001..60207125, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 155 Neighboring gene uncharacterized LOC134486289 Neighboring gene uncharacterized LOC134486113 Neighboring gene uncharacterized LOC134486112 Neighboring gene uncharacterized LOC108350398 Neighboring gene ring-box 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. Peterson FC, et al. J Biol Chem, 2007 Mar 16. PMID 17229736
    2. The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. Vetterkind S, et al. J Biol Chem, 2002 Jan 4. PMID 11687573
    3. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Volkman BF, et al. Cell, 2002 Nov 15. PMID 12437929
    4. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Garber JJ, et al. Infect Immun, 2012 Dec. PMID 22966049, Free PMC Article
    5. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. Lee S, et al. EMBO J, 2006 Oct 18. PMID 16990791, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP
      Title: Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to other organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to other organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WAS/WASL-interacting protein family member 1
    Names
    WASP-interacting protein
    Wiskott-Aldrich syndrome protein interacting protein
    translation initiation factor IF-2-like
    wiskott-Aldrich syndrome protein-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429723.1 → NP_001416652.1  WAS/WASL-interacting protein family member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6IN36, Q8VDA4
      UniProtKB/TrEMBL
      A6HM96, R9PXW1

    2. NM_001429724.1 → NP_001416653.1  WAS/WASL-interacting protein family member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6IN36, Q8VDA4
      UniProtKB/TrEMBL
      A6HM96, R9PXW1

    3. NM_001429725.1 → NP_001416654.1  WAS/WASL-interacting protein family member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6IN36, Q8VDA4
      UniProtKB/TrEMBL
      A6HM96, R9PXW1

    4. NM_001429726.1 → NP_001416655.1  WAS/WASL-interacting protein family member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6IN36, Q8VDA4
      UniProtKB/TrEMBL
      A6HM96, R9PXW1

    5. NM_057192.2 → NP_476540.2  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_476540.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072475
      UniProtKB/Swiss-Prot
      Q6IN36, Q8VDA4
      UniProtKB/TrEMBL
      A6HM96, R9PXW1
      Related
      ENSRNOP00000024922.6, ENSRNOT00000024922.8
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78721486..78824199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104135.2 → XP_038960063.1  WAS/WASL-interacting protein family member 1 isoform X1

      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    2. XM_039104136.2 → XP_038960064.1  WAS/WASL-interacting protein family member 1 isoform X1

      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    3. XM_039104137.2 → XP_038960065.1  WAS/WASL-interacting protein family member 1 isoform X1

      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    4. XM_039104138.2 → XP_038960066.1  WAS/WASL-interacting protein family member 1 isoform X1

      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IN36.2 GenPept UniProtKB/Swiss-Prot:Q6IN36

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