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    Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcne3provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily E regulatory subunit 3provided by RGD
    Primary source
    RGD:621384
    See related
    EnsemblRapid:ENSRNOG00000063050 AllianceGenome:RGD:621384
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MiRP2
    Summary
    Enables potassium channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of delayed rectifier potassium channel activity and positive regulation of voltage-gated calcium channel activity. Located in plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 30.9), Uterus (RPKM 19.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcne3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (163936035..163942998)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154523903..154530865)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165189934..165196949)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 3, accessory subunit Neighboring gene uncharacterized LOC100912071 Neighboring gene lipoyl(octanoyl) transferase 2 Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene prolyl 4-hydroxylase subunit alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis transmembrane conductance regulator. Boucherot A, et al. J Membr Biol, 2001 Jul 1. PMID 11426298
    2. KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram. Nakajima T, et al. Circ J, 2012. PMID 22987075
    3. Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K⁺ channels. Alzamora R, et al. J Physiol, 2011 Nov 1. PMID 21911611, Free PMC Article
    4. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Abbott GW, et al. Cell, 2001 Jan 26. PMID 11207363
    5. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, et al. J Biol Chem, 2004 Feb 27. PMID 14679187

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105432

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane repolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane repolarization during ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily E member 3
    Names
    minimum potassium ion channel-related peptide 2
    mink-related peptide 2
    potassium channel subunit beta MiRP2
    potassium channel, voltage gated subfamily E regulatory beta subunit 3
    potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3
    potassium voltage-gated channel, Isk-related family, member 3
    potassium voltage-gated channel, Isk-related subfamily, gene 3
    potassium voltage-gated channel, Isk-related subfamily, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022235.2 → NP_071571.1  potassium voltage-gated channel subfamily E member 3

      See identical proteins and their annotated locations for NP_071571.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086406
      UniProtKB/Swiss-Prot
      Q9JJV7
      UniProtKB/TrEMBL
      A6I6L9
      Related
      ENSRNOP00000098796.1, ENSRNOT00000155651.1
      Conserved Domains (1) summary
      pfam02060
      Location:46 → 100
      ISK_Channel; Slow voltage-gated potassium channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      163936035..163942998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJV7.1 GenPept UniProtKB/Swiss-Prot:Q9JJV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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