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    Sipa1l2 signal-induced proliferation-associated 1 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sipa1l2provided by RGD
    Official Full Name
    signal-induced proliferation-associated 1 like 2provided by RGD
    Primary source
    RGD:1306269
    See related
    EnsemblRapid:ENSRNOG00000019791 AllianceGenome:RGD:1306269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spar2; Sersap2
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in presynaptic signal transduction. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 139.7), Lung (RPKM 120.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sipa1l2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (70287134..70437810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (53389792..53540466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (58236201..58399842, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557452 Neighboring gene uncharacterized LOC134483660 Neighboring gene SET like protein Neighboring gene uncharacterized LOC120098601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A. Tao F, et al. Ann Neurol, 2019 Mar. PMID 30706531, Free PMC Article
    2. SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2. Spilker C, et al. J Neurochem, 2008 Jan. PMID 17961154
    3. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Andres-Alonso M, et al. Nat Commun, 2019 Nov 29. PMID 31784514, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro knockdown of SIPA1L2 in Schwannoma cells led to a significant reduction of PMP22 expression.
      Title: Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A.
    2. SPAR2 is a new RapGAP with specific functions in cerebellar and hippocampal granule cells.
      Title: SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in presynaptic signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynaptic signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal-induced proliferation-associated 1-like protein 2
    Names
    SIPA1-like protein 2
    serine-rich synapse associated protein 2
    serine-rich synapse-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009704.2 → NP_001009704.2  signal-induced proliferation-associated 1-like protein 2 isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5JCS6
      UniProtKB/TrEMBL
      F1M8G8
      Related
      ENSRNOP00000026843.8, ENSRNOT00000026843.9
      Conserved Domains (3) summary
      cd00992
      Location:951 → 1021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626 → 806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:1423 → 1666
      SPAR_C; C-terminal domain of SPAR protein

    2. NM_001434585.1 → NP_001421514.1  signal-induced proliferation-associated 1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5JCS6
      UniProtKB/TrEMBL
      A0A8I6G2L5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      70287134..70437810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772639.3 → XP_008770861.1  signal-induced proliferation-associated 1-like protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5JCS6
      UniProtKB/TrEMBL
      A0A8I5ZPJ4
      Related
      ENSRNOP00000080159.1, ENSRNOT00000112190.2
      Conserved Domains (3) summary
      cd00992
      Location:951 → 1021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626 → 806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:1423 → 1604
      SPAR_C; C-terminal domain of SPAR protein

    2. XM_039097901.2 → XP_038953829.1  signal-induced proliferation-associated 1-like protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5JCS6
      Related
      ENSRNOP00000111286.1, ENSRNOT00000159211.1
      Conserved Domains (3) summary
      cd00992
      Location:951 → 1021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626 → 806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:1423 → 1622
      SPAR_C; C-terminal domain of SPAR protein

    3. XM_008772638.3 → XP_008770860.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

      Related
      ENSRNOP00000104554.1, ENSRNOT00000159555.1
      Conserved Domains (3) summary
      cd00992
      Location:951 → 1021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626 → 806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:1423 → 1648
      SPAR_C; C-terminal domain of SPAR protein

    4. XM_039097900.2 → XP_038953828.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5JCS6
      Related
      ENSRNOP00000078337.2, ENSRNOT00000096967.2
      Conserved Domains (3) summary
      cd00992
      Location:951 → 1021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626 → 806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:1423 → 1685
      SPAR_C; C-terminal domain of SPAR protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JCS6.1 GenPept UniProtKB/Swiss-Prot:Q5JCS6

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