Chordc1 cysteine and histidine rich domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chordc1provided by RGD
Official Full Name: cysteine and histidine rich domain containing 1provided by RGD
Primary source: RGD:1304679
See related: EnsemblRapid:ENSRNOG00000026643 AllianceGenome:RGD:1304679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CHP-1
Summary: Predicted to enable Hsp90 protein binding activity; adenyl ribonucleotide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including centrosome duplication; chaperone-mediated protein folding; and negative regulation of Rho-dependent protein serine/threonine kinase activity. Orthologous to human CHORDC1 (cysteine and histidine rich domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 269.7), Muscle (RPKM 264.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (23650721..23674786)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (15374356..15398436)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (17421552..17445513)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE120647 (e-PCR)
- UniSTS:247405

RH139249 (e-PCR)
- UniSTS:221335

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
NOT enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome duplication	IEA Inferred from Electronic Annotation more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cysteine and histidine-rich domain-containing protein 1

Names: CHORD domain-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1; morgana

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108128.1 → NP_001101598.1 cysteine and histidine-rich domain-containing protein 1

See identical proteins and their annotated locations for NP_001101598.1

Status: PROVISIONAL

Source sequence(s)

CH473993

UniProtKB/Swiss-Prot

D4A4T9

UniProtKB/TrEMBL

A0A8L2QG05

Related

ENSRNOP00000030171.6, ENSRNOT00000030569.7

Conserved Domains (2) summary

cd06488
Location:230 → 316

p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...

pfam04968
Location:3 → 64

CHORD; CHORD