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    Pomk protein-O-mannose kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306549, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pomkprovided by RGD
    Official Full Name
    protein-O-mannose kinaseprovided by RGD
    Primary source
    RGD:1310810
    See related
    EnsemblRapid:ENSRNOG00000014628 AllianceGenome:RGD:1310810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sgk196; RGD1310810
    Summary
    Predicted to enable carbohydrate kinase activity and phosphotransferase activity, alcohol group as acceptor. Predicted to be involved in carbohydrate phosphorylation and protein O-linked glycosylation. Predicted to act upstream of or within several processes, including learning or memory; neuromuscular process; and sensory perception of pain. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A12 and muscular dystrophy-dystroglycanopathy type C12. Orthologous to human POMK (protein O-mannose kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 78.6), Brain (RPKM 76.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pomk in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72788842..72801122)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66085569..66101360)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (70854825..70869653)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene hook microtubule-tethering protein 3 Neighboring gene farnesyltransferase, CAAX box, subunit alpha Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 5 Neighboring gene potassium calcium-activated channel subfamily U member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835
    2. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114531

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein O-mannose kinase
    Names
    probable inactive protein kinase-like protein SgK196
    protein kinase-like protein SgK196
    sugen kinase 196
    NP_001020054.1
    XP_008769575.1
    XP_038950484.1
    XP_038950485.1
    XP_038950486.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024883.1 → NP_001020054.1  protein O-mannose kinase

      See identical proteins and their annotated locations for NP_001020054.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097466
      UniProtKB/Swiss-Prot
      Q4V8A9
      UniProtKB/TrEMBL
      A0A8I6A6B4, A6IVZ8
      Related
      ENSRNOP00000019630.4, ENSRNOT00000019630.9
      Conserved Domains (1) summary
      cl21453
      Location:104 → 194
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      72788842..72801122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094556.2 → XP_038950484.1  protein O-mannose kinase isoform X1

      UniProtKB/Swiss-Prot
      Q4V8A9
      UniProtKB/TrEMBL
      A0A8I6A6B4, A6IVZ8
      Conserved Domains (1) summary
      cl21453
      Location:104 → 194
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039094558.2 → XP_038950486.1  protein O-mannose kinase isoform X1

      UniProtKB/Swiss-Prot
      Q4V8A9
      UniProtKB/TrEMBL
      A0A8I6A6B4, A6IVZ8
      Conserved Domains (1) summary
      cl21453
      Location:104 → 194
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039094557.2 → XP_038950485.1  protein O-mannose kinase isoform X1

      UniProtKB/Swiss-Prot
      Q4V8A9
      UniProtKB/TrEMBL
      A0A8I6A6B4, A6IVZ8
      Conserved Domains (1) summary
      cl21453
      Location:104 → 194
      PKc_like; Protein Kinases, catalytic domain

    4. XM_008771353.4 → XP_008769575.1  protein O-mannose kinase isoform X1

      See identical proteins and their annotated locations for XP_008769575.1

      UniProtKB/Swiss-Prot
      Q4V8A9
      UniProtKB/TrEMBL
      A0A8I6A6B4, A6IVZ8
      Conserved Domains (1) summary
      cl21453
      Location:104 → 194
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8A9.1 GenPept UniProtKB/Swiss-Prot:Q4V8A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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