Shisa7 shisa family member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shisa7provided by RGD
Official Full Name: shisa family member 7provided by RGD
Primary source: RGD:1583944
See related: EnsemblRapid:ENSRNOG00000016877 AllianceGenome:RGD:1583944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GABA receptor binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 25.3), Testes (RPKM 6.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78022680..78041748)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68993900..69012943)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72545413..72564513)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH134728 (e-PCR)
- UniSTS:218006

RH136714 (e-PCR)
- UniSTS:218803

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
NOT enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
NOT located_in asymmetric, glutamatergic, excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in asymmetric, glutamatergic, excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine membrane	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein shisa-7

Names: shisa homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145175.1 → NP_001138647.1 protein shisa-7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZPJ0

Related

ENSRNOP00000022698.3, ENSRNOT00000022698.5

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

78022680..78041748

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274859.1 → XP_063130929.1 protein shisa-7 isoform X2

Related

ENSRNOP00000108986.1, ENSRNOT00000161994.1
XM_017589753.3 → XP_017445242.1 protein shisa-7 isoform X1

UniProtKB/TrEMBL

D3ZPJ0

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_039091565.2 → XP_038947493.1 protein shisa-7 isoform X3

UniProtKB/TrEMBL

A0A8I6ANL3

Related

ENSRNOP00000094674.1, ENSRNOT00000114646.2

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_039091559.2 → XP_038947487.1 protein shisa-7 isoform X1

UniProtKB/TrEMBL

D3ZPJ0

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_017589754.3 → XP_017445243.1 protein shisa-7 isoform X1

UniProtKB/TrEMBL

D3ZPJ0

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_017589755.3 → XP_017445244.1 protein shisa-7 isoform X1

UniProtKB/TrEMBL

D3ZPJ0

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_063274863.1 → XP_063130933.1 protein shisa-7 isoform X4

UniProtKB/TrEMBL

A6KNP6