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    Ppil3 peptidylprolyl isomerase like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppil3provided by RGD
    Official Full Name
    peptidylprolyl isomerase like 3provided by RGD
    Primary source
    RGD:631415
    See related
    EnsemblRapid:ENSRNOG00000013636 AllianceGenome:RGD:631415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp10l
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL3 (peptidylprolyl isomerase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 109.1), Muscle (RPKM 81.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppil3 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67460594..67474325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59966405..59980147, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65315407..65329145, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 1 Neighboring gene uncharacterized LOC134480578 Neighboring gene U2 spliceosomal RNA Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene origin recognition complex, subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spliceosomal immunophilins. Mesa A, et al. FEBS Lett, 2008 Jul 9. PMID 18544344, Free PMC Article
    2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105285

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase-like 3
    Names
    PPIase
    cyclophilin-like protein 3
    cyclophilin-like protein PPIL3
    peptidylprolyl cis-trans isomerase-like protein 3
    peptidylprolyl isomerase (cyclophilin)-like 3
    rotamase PPIL3
    NP_783638.1
    XP_006245026.1
    XP_017451851.1
    XP_038939239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175707.3 → NP_783638.1  peptidyl-prolyl cis-trans isomerase-like 3

      See identical proteins and their annotated locations for NP_783638.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087645
      UniProtKB/Swiss-Prot
      Q812D3
      UniProtKB/TrEMBL
      A0A8L2Q9D4, A6IP66
      Related
      ENSRNOP00000079425.1, ENSRNOT00000103798.2
      Conserved Domains (1) summary
      cd01928
      Location:1 → 154
      Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67460594..67474325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596362.3 → XP_017451851.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

      UniProtKB/Swiss-Prot
      Q812D3
      UniProtKB/TrEMBL
      A0A8L2Q9D4, A6IP66
      Conserved Domains (1) summary
      cd01928
      Location:1 → 154
      Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

    2. XM_006244964.5 → XP_006245026.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

      See identical proteins and their annotated locations for XP_006245026.1

      UniProtKB/Swiss-Prot
      Q812D3
      UniProtKB/TrEMBL
      A0A8L2Q9D4, A6IP66
      Related
      ENSRNOP00000018284.6, ENSRNOT00000018284.7
      Conserved Domains (1) summary
      cd01928
      Location:1 → 154
      Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

    3. XM_039083311.2 → XP_038939239.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

      Conserved Domains (1) summary
      cd01928
      Location:1 → 120
      Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q812D3.1 GenPept UniProtKB/Swiss-Prot:Q812D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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