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    Pigo phosphatidylinositol glycan anchor biosynthesis, class O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pigoprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Oprovided by RGD
    Primary source
    RGD:1309498
    See related
    EnsemblRapid:ENSRNOG00000009930 AllianceGenome:RGD:1309498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 41.6), Thymus (RPKM 30.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigo in Genome Data Viewer
    Location:
    5q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62040979..62052067, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57244721..57256252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58461055..58470699, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene valosin-containing protein Neighboring gene FA complementation group G Neighboring gene stomatin like 2 Neighboring gene atos homolog B Neighboring gene unc-13 homolog B Neighboring gene ribosomal protein L39, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vitamin B6-responsive epilepsy due to inherited GPI deficiency. Kuki I, et al. Neurology, 2013 Oct 15. PMID 24049131
    2. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 3
    Names
    phosphatidylinositol glycan, class O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431175.1 → NP_001418104.1  GPI ethanolamine phosphate transferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZTP8

    2. NM_001431176.1 → NP_001418105.1  GPI ethanolamine phosphate transferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZTP8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      62040979..62052067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110982.1 → XP_038966910.1  GPI ethanolamine phosphate transferase 3 isoform X1

      UniProtKB/TrEMBL
      D3ZTP8
      Related
      ENSRNOP00000102008.1, ENSRNOT00000164556.1
      Conserved Domains (1) summary
      cd16023
      Location:85 → 365
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    2. XM_039110981.2 → XP_038966909.1  GPI ethanolamine phosphate transferase 3 isoform X1

      UniProtKB/TrEMBL
      D3ZTP8
      Conserved Domains (1) summary
      cd16023
      Location:85 → 365
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    3. XM_233141.11 → XP_233141.7  GPI ethanolamine phosphate transferase 3 isoform X2

      See identical proteins and their annotated locations for XP_233141.7

      UniProtKB/TrEMBL
      A0A8I5ZR91, D3ZTP8
      Related
      ENSRNOP00000103342.1, ENSRNOT00000124803.1
      Conserved Domains (2) summary
      COG1524
      Location:63 → 360
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16023
      Location:85 → 365
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    4. XM_039110983.2 → XP_038966911.1  GPI ethanolamine phosphate transferase 3 isoform X3

      UniProtKB/TrEMBL
      D3ZTP8
      Related
      ENSRNOP00000091520.2, ENSRNOT00000118014.2
      Conserved Domains (1) summary
      cd16023
      Location:64 → 344
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    5. XM_039110984.2 → XP_038966912.1  GPI ethanolamine phosphate transferase 3 isoform X5

      Conserved Domains (1) summary
      cl23718
      Location:1 → 65
      ALP_like; alkaline phosphatases and sulfatases

    6. XM_063288526.1 → XP_063144596.1  GPI ethanolamine phosphate transferase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A4S1
    Nucleotide Protein Strain
    Heading Accession and Version

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