Tp53inp2 tumor protein p53 inducible nuclear protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tp53inp2provided by RGD
Official Full Name: tumor protein p53 inducible nuclear protein 2provided by RGD
Primary source: RGD:735085
See related: EnsemblRapid:ENSRNOG00000018225 AllianceGenome:RGD:735085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trp53inp2
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in autophagosome assembly and positive regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 308.4), Muscle (RPKM 289.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164341618..164350270)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (143881427..143890104)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (150910398..150918525)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-362-3p Implicated in Cardioprotection Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing TP53INP2 and Regulating SDF-1/CXCR4 Pathway.
Title: MicroRNA-362-3p Implicated in Cardioprotection Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing TP53INP2 and Regulating SDF-1/CXCR4 Pathway.
Tp53inp2 is an atypical mRNA that regulates axon growth by enhancing NGF-TrkA signaling in a translation-independent manner.
Title: Regulation of NGF Signaling by an Axonal Untranslated mRNA.
Trp53inp2 gene knockdown in rat cardiomyocytes reduced expression and protein abundance of key glycolytic enzymes
Title: A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein localization	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tumor protein p53-inducible nuclear protein 2

Names: diabetes and obesity-regulated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270947.1 → NP_001257876.1 tumor protein p53-inducible nuclear protein 2

See identical proteins and their annotated locations for NP_001257876.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8CHM3

UniProtKB/TrEMBL

A6KI33, G3V9L6

Conserved Domains (1) summary

pfam14839
Location:67 → 212

DOR; DOR family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

164341618..164350270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105490.2 → XP_038961418.1 tumor protein p53-inducible nuclear protein 2 isoform X2

Conserved Domains (1) summary

pfam14839
Location:45 → 172

DOR; DOR family
XM_063284177.1 → XP_063140247.1 tumor protein p53-inducible nuclear protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8CHM3

UniProtKB/TrEMBL

A6KI33, G3V9L6
XM_063284178.1 → XP_063140248.1 tumor protein p53-inducible nuclear protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8CHM3

UniProtKB/TrEMBL

A6KI33, G3V9L6

Related

ENSRNOP00000052180.2, ENSRNOT00000055310.6
XM_003749598.5 → XP_003749646.1 tumor protein p53-inducible nuclear protein 2 isoform X1

See identical proteins and their annotated locations for XP_003749646.1

UniProtKB/Swiss-Prot

Q8CHM3

UniProtKB/TrEMBL

A6KI33, G3V9L6

Conserved Domains (1) summary

pfam14839
Location:67 → 212

DOR; DOR family
XM_039105489.2 → XP_038961417.1 tumor protein p53-inducible nuclear protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8CHM3

UniProtKB/TrEMBL

A6KI33, G3V9L6

Conserved Domains (1) summary

pfam14839
Location:67 → 212

DOR; DOR family
XM_039105491.2 → XP_038961419.1 tumor protein p53-inducible nuclear protein 2 isoform X3

Conserved Domains (1) summary

pfam14839
Location:9 → 136

DOR; DOR family