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    CG3473 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3473provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028913
    Locus tag
    Dmel_CG3473
    See related
    AllianceGenome:FB:FBgn0028913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT16033; BG:DS01486.1; cg3473; Dmel\CG3473; Ube2N
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in postreplication repair and protein K63-linked ubiquitination. Predicted to be part of ubiquitin conjugating enzyme complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N) and UBE2NL (ubiquitin conjugating enzyme E2 N like (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3473 in Genome Data Viewer
    Location:
    35B3-35B3; 2-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14563015..14563726, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14563015..14563726, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44854 Neighboring gene long non-coding RNA:CR44855 Neighboring gene long non-coding RNA:CR44856 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
    2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. Hallacli E, et al. Mol Cell, 2012 Nov 30. PMID 23084835
    3. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. McPhee CK, et al. Cell Death Differ, 2013 Feb. PMID 22935612, Free PMC Article
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin conjugating enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3473-PA
    CG3473-PB
    NP_001285937.1
    NP_609715.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14563015..14563726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299008.1 → NP_001285937.1  uncharacterized protein Dmel_CG3473, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJS5
      Conserved Domains (2) summary
      COG5078
      Location:7 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:3 → 151
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_135871.3 → NP_609715.1  uncharacterized protein Dmel_CG3473, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJS5
      Related
      FBpp0080227
      Conserved Domains (2) summary
      COG5078
      Location:7 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:3 → 151
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJS5 Q9VJS5

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