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    Edf1 endothelial differentiation-related factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296570, updated on 9-Dec-2024

    Summary

    Official Symbol
    Edf1provided by RGD
    Official Full Name
    endothelial differentiation-related factor 1provided by RGD
    Primary source
    RGD:1308073
    See related
    EnsemblRapid:ENSRNOG00000084601 AllianceGenome:RGD:1308073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAP-19
    Summary
    Predicted to enable TFIID-class transcription factor complex binding activity and transcription coactivator activity. Predicted to be involved in cell differentiation and positive regulation of DNA-templated transcription. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 488.9), Thymus (RPKM 468.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Edf1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28764906..28779499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8377058..8381363)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2781169..2785474)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene Tnf receptor-associated factor 2 Neighboring gene MAM domain containing 4 Neighboring gene phosphohistidine phosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endothelial differentiation-related factor 1
    Names
    EDF-1
    MBF1
    calmodulin-associated peptide-19
    endothelial differentiation-related factor 1 homolog
    multiprotein-bridging factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106557.1NP_001100027.1  endothelial differentiation-related factor 1

      See identical proteins and their annotated locations for NP_001100027.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/Swiss-Prot
      P69736
      UniProtKB/TrEMBL
      B0BNJ5
      Conserved Domains (2) summary
      cl26727
      Location:48142
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:571
      MBF1; Multiprotein bridging factor 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28764906..28779499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283463.1XP_063139533.1  endothelial differentiation-related factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QBB2
      Related
      ENSRNOP00000100040.1, ENSRNOT00000132385.1