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    Wnt5b Wnt family member 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wnt5bprovided by RGD
    Official Full Name
    Wnt family member 5Bprovided by RGD
    Primary source
    RGD:628850
    See related
    EnsemblRapid:ENSRNOG00000008168 AllianceGenome:RGD:628850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; chondrocyte differentiation; and positive regulation of cell migration. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in extracellular space. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 24.3), Lung (RPKM 21.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wnt5b in Genome Data Viewer
    Location:
    4q42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154281852..154406081, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (152609566..152733790, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (151500962..151516894, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134486631 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene uncharacterized LOC134486632 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Lyu J, et al. Cornea, 2006 Dec. PMID 17001188
    2. Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor. Mangioni S, et al. J Clin Endocrinol Metab, 2005 Sep. PMID 15972578
    3. Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea. Daudet N, et al. Brain Res Mol Brain Res, 2002 Sep 30. PMID 12399112
    4. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Morioka K, et al. Cancer Sci, 2009 Jul. PMID 19486338, Free PMC Article
    5. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Kanazawa A, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796911

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Wnt-5b
    Names
    wingless-related MMTV integration site 5B
    wingless-type MMTV integration site family, member 5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100489.1 → NP_001093959.1  protein Wnt-5b

      See identical proteins and their annotated locations for NP_001093959.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      B1WBR9, F7FL18
      Related
      ENSRNOP00000108118.1, ENSRNOT00000170580.1
      Conserved Domains (1) summary
      cl38924
      Location:61 → 372
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      154281852..154406081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107158.2 → XP_038963086.1  protein Wnt-5b isoform X1

      UniProtKB/TrEMBL
      B1WBR9, F7FL18
      Conserved Domains (1) summary
      cl38924
      Location:61 → 372
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    2. XM_039107157.2 → XP_038963085.1  protein Wnt-5b isoform X1

      UniProtKB/TrEMBL
      B1WBR9, F7FL18
      Related
      ENSRNOP00000011044.5, ENSRNOT00000011044.6
      Conserved Domains (1) summary
      cl38924
      Location:61 → 372
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    3. XM_063285651.1 → XP_063141721.1  protein Wnt-5b isoform X1

      UniProtKB/TrEMBL
      B1WBR9, F7FL18
      Related
      ENSRNOP00000107700.1, ENSRNOT00000159923.1
    Nucleotide Protein Strain
    Heading Accession and Version

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