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    Zfhx3 zinc finger homeobox 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307829, updated on 9-Dec-2024

    Summary

    Symbol
    Zfhx3provided by RGD
    Full Name
    zinc finger homeobox 3provided by RGD
    Primary source
    RGD:1560268
    See related
    EnsemblRapid:ENSRNOG00000014452 AllianceGenome:RGD:1560268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atbf1; RGD1560268
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in regulation of neuron differentiation. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); prostate cancer; and spinocerebellar ataxia type 4. Orthologous to human ZFHX3 (zinc finger homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 66.6), Lung (RPKM 34.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfhx3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (52789146..53795664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (36257196..36886104)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42753983..42925794, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483638 Neighboring gene uncharacterized LOC134483513 Neighboring gene uncharacterized LOC120098516 Neighboring gene uncharacterized LOC134483353 Neighboring gene uncharacterized LOC134483639 Neighboring gene uncharacterized LOC134483640 Neighboring gene uncharacterized LOC103694327 Neighboring gene transfer RNA threonine (anticodon AGU) 21 Neighboring gene uncharacterized LOC108353195 Neighboring gene zinc finger homeobox 3 like Neighboring gene uncharacterized LOC120098527 Neighboring gene uncharacterized LOC120098483

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger homeobox protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427481.2NP_001414410.1  zinc finger homeobox protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F1M4Q6
      Related
      ENSRNOP00000098452.1, ENSRNOT00000120840.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      52789146..53795664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278047.1XP_063134117.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
    2. XM_039098313.2XP_038954241.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
      Conserved Domains (5) summary
      smart00389
      Location:21562212
      HOX; Homeodomain
      COG5576
      Location:26042750
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15561580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14121432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22562310
      Homeobox; Homeobox domain
    3. XM_039098314.2XP_038954242.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
      Conserved Domains (5) summary
      smart00389
      Location:21562212
      HOX; Homeodomain
      COG5576
      Location:26042750
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15561580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14121432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22562310
      Homeobox; Homeobox domain
    4. XM_063278048.1XP_063134118.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
    5. XM_039098312.2XP_038954240.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
      Conserved Domains (5) summary
      smart00389
      Location:21562212
      HOX; Homeodomain
      COG5576
      Location:26042750
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15561580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14121432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22562310
      Homeobox; Homeobox domain
    6. XM_039098319.2XP_038954247.1  zinc finger homeobox protein 3 isoform X2

      Conserved Domains (5) summary
      smart00389
      Location:12431299
      HOX; Homeodomain
      COG5576
      Location:16911837
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:643667
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:499519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:13431397
      Homeobox; Homeobox domain
    7. XM_039098318.2XP_038954246.1  zinc finger homeobox protein 3 isoform X2

      Conserved Domains (5) summary
      smart00389
      Location:12431299
      HOX; Homeodomain
      COG5576
      Location:16911837
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:643667
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:499519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:13431397
      Homeobox; Homeobox domain
    8. XM_039098311.2XP_038954239.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
      Conserved Domains (5) summary
      smart00389
      Location:21562212
      HOX; Homeodomain
      COG5576
      Location:26042750
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15561580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14121432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22562310
      Homeobox; Homeobox domain
    9. XM_039098317.2XP_038954245.1  zinc finger homeobox protein 3 isoform X2

      Conserved Domains (5) summary
      smart00389
      Location:12431299
      HOX; Homeodomain
      COG5576
      Location:16911837
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:643667
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:499519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:13431397
      Homeobox; Homeobox domain
    10. XM_039098316.2XP_038954244.1  zinc finger homeobox protein 3 isoform X1

      UniProtKB/TrEMBL
      F1M4Q6
      Conserved Domains (5) summary
      smart00389
      Location:21562212
      HOX; Homeodomain
      COG5576
      Location:26042750
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15561580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14121432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22562310
      Homeobox; Homeobox domain