U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498233, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lgr6provided by RGD
    Official Full Name
    leucine-rich repeat-containing G protein-coupled receptor 6provided by RGD
    Primary source
    RGD:1560339
    See related
    EnsemblRapid:ENSRNOG00000005093 AllianceGenome:RGD:1560339
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560339
    Summary
    Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in several processes, including axon guidance; negative chemotaxis; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within bone regeneration and cell population proliferation. Predicted to be located in vesicle. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 53.6), Lung (RPKM 11.1) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lgr6 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48976193..49095870, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46424382..46544074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51811904..51931193, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 4 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene uncharacterized LOC120096252 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene protein tyrosine phosphatase, non-receptor type 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lgr6 marks nail stem cells and is required for digit tip regeneration. Lehoczky JA, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26460010, Free PMC Article
    2. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. Gong X, et al. PLoS One, 2012. PMID 22615920, Free PMC Article
    3. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Roundabout binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bone regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427357.2 → NP_001414286.1  leucine-rich repeat-containing G-protein coupled receptor 6 precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICD4, D3ZJU9
      Related
      ENSRNOP00000006969.4, ENSRNOT00000006969.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48976193..49095870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091316.2 → XP_038947244.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

      UniProtKB/TrEMBL
      A6ICD4
      Related
      ENSRNOP00000110269.1, ENSRNOT00000135242.1
      Conserved Domains (5) summary
      smart00013
      Location:34 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:60 → 429
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:330 → 344
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:70 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      cd15362
      Location:520 → 796
      7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools