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    Igsf8 immunoglobulin superfamily, member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igsf8provided by RGD
    Official Full Name
    immunoglobulin superfamily, member 8provided by RGD
    Primary source
    RGD:1311500
    See related
    EnsemblRapid:ENSRNOG00000007604 AllianceGenome:RGD:1311500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in modulation of chemical synaptic transmission and positive regulation of cell migration. Predicted to act upstream of or within regulation of cell motility. Is active in hippocampal mossy fiber to CA3 synapse and presynaptic membrane. Orthologous to human IGSF8 (immunoglobulin superfamily member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 154.4), Adrenal (RPKM 50.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igsf8 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87282015..87314018)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84770348..84781534)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90692590..90703262)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calsequestrin 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4 Neighboring gene ATPase Na+/K+ transporting subunit alpha 2 Neighboring gene uncharacterized LOC134481592 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer. Apóstolo N, et al. Nat Commun, 2020 Oct 14. PMID 33057002, Free PMC Article
    2. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. Clark KL, et al. J Immunol, 2001 Nov 1. PMID 11673522
    3. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. Stipp CS, et al. J Biol Chem, 2001 Nov 2. PMID 11504738
    4. IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Ray A, et al. Mol Cell Neurosci, 2012 Jul. PMID 22687584, Free PMC Article
    5. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105805

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014787.2 → NP_001014787.1  immunoglobulin superfamily member 8 precursor

      See identical proteins and their annotated locations for NP_001014787.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A140TAA1
      Conserved Domains (2) summary
      cd00096
      Location:41 → 49
      Ig; Ig strand B [structural motif]
      cl11960
      Location:40 → 147
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      87282015..87314018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272372.1 → XP_063128442.1  immunoglobulin superfamily member 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBJ3

    2. XM_017598830.3 → XP_017454319.2  immunoglobulin superfamily member 8 isoform X1

      UniProtKB/TrEMBL
      A0A140TAA1, A0A8I6ANQ3
      Related
      ENSRNOP00000095607.1, ENSRNOT00000102622.2
      Conserved Domains (2) summary
      cd00096
      Location:91 → 99
      Ig; Ig strand B [structural motif]
      cl11960
      Location:90 → 197
      Ig; Immunoglobulin domain

    3. XM_006250289.5 → XP_006250351.1  immunoglobulin superfamily member 8 isoform X4

      UniProtKB/TrEMBL
      A0A140TAA1
      Conserved Domains (1) summary
      cl11960
      Location:385 → 493
      Ig; Immunoglobulin domain

    4. XM_039090796.2 → XP_038946724.1  immunoglobulin superfamily member 8 isoform X2

      UniProtKB/TrEMBL
      A0A140TAA1
      Conserved Domains (2) summary
      cd00096
      Location:41 → 49
      Ig; Ig strand B [structural motif]
      cl11960
      Location:40 → 147
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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