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    Eftud2 elongation factor Tu GTP binding domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eftud2provided by RGD
    Official Full Name
    elongation factor Tu GTP binding domain containing 2provided by RGD
    Primary source
    RGD:1560116
    See related
    EnsemblRapid:ENSRNOG00000002818 AllianceGenome:RGD:1560116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity and U5 snRNA binding activity. Involved in cellular response to xenobiotic stimulus and response to cocaine. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in esophageal atresia; hepatitis B; hepatocellular carcinoma; mandibulofacial dysostosis, Guion-Almeida type; and microcephaly. Orthologous to human EFTUD2 (elongation factor Tu GTP binding domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 147.2), Thymus (RPKM 135.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eftud2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88304992..88352229, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87804893..87852181, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90932071..90983971, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gap junction protein, gamma 1 Neighboring gene HIG1 hypoxia inducible domain family, member 1B Neighboring gene dynein axonemal assembly factor 19 Neighboring gene family with sequence similarity 187, member A Neighboring gene glial fibrillary acidic protein Neighboring gene kinesin family member 18B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma. Lv C, et al. Clin Transl Oncol, 2022 Jan. PMID 34282556
    2. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. Freeman WM, et al. BMC Neurosci, 2010 Feb 26. PMID 20187946, Free PMC Article
    3. Investigation of the hepatotoxicity of flutamide: pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips. Legendre A, et al. Toxicol In Vitro, 2014 Aug. PMID 24793618
    4. Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole. Löb S, et al. J Reprod Immunol, 2020 Aug. PMID 32447180
    5. Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage. Lv Z, et al. Mucosal Immunol, 2019 Sep. PMID 31278373

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U5 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cocaine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    116 kDa U5 small nuclear ribonucleoprotein component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398598.1 → NP_001385527.1  116 kDa U5 small nuclear ribonucleoprotein component isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A4V7, F1LM66
      Conserved Domains (2) summary
      cl30786
      Location:122 → 954
      FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam16004
      Location:4 → 110
      EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component N-terminus

    2. NM_001398599.1 → NP_001385528.1  116 kDa U5 small nuclear ribonucleoprotein component isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A4V7
      Related
      ENSRNOP00000052049.4, ENSRNOT00000055176.5
      Conserved Domains (2) summary
      pfam16004
      Location:4 → 109
      EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
      cl30786
      Location:121 → 953
      PLN00116; translation elongation factor EF-2 subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88304992..88352229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268747.1 → XP_063124817.1  116 kDa U5 small nuclear ribonucleoprotein component isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4V7, F1LM66

    2. XM_063268748.1 → XP_063124818.1  116 kDa U5 small nuclear ribonucleoprotein component isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4V7

    3. XM_039087769.2 → XP_038943697.1  116 kDa U5 small nuclear ribonucleoprotein component isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4V7, F1LM66
      Conserved Domains (2) summary
      cl30786
      Location:122 → 954
      FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam16004
      Location:4 → 110
      EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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